Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy  

作　　者：He Lian Zhaoxu Meng 

机构地区：[1]Department of Biomedical Engineering,School of Medical Devices,Shenyang Pharmaceutical University,Shenyang,110016,China

出　　处：《Bioactive Materials》2017年第2期96-100,共5页生物活性材料（英文）

基　　金：This work is supported by the Scientific Research General Project of Liaoning Provincial Department of Education(No.L2014388);the Natural Science Foundation of Liaoning Province(No.2015020753);Nature Science Foundation of China(No.81503020,No.31600767).

摘　　要：Daunorubicin hydrochloride is a cell-cycle non-specific antitumor drug with a high therapeutic effect.The present study outlines the fabrication of daunorubicin hydrochloride-loaded poly (ε-caprolactone)(PCL) fibrous membranes by melt electrospinning for potential application in localized tumor therapy.The diameters of the drug-loaded fibers prepared with varying concentrations of daunorubicin hydrochloride(1, 5, and 10 wt%) were 2.48 ± 1.25, 2.51 ± 0.78, and 2.49 ± 1.58 μm, respectively. Fluorescenceimages indicated that the hydrophobic drug was dispersed in the hydrophilic PCL fibers in theiraggregated state. The drug release profiles of the drug-loaded PCL melt electrospun fibrous membraneswere approximately linear, with slow release rates and long-term release periods, and no observed burstrelease. The MTT assay was used to examine the cytotoxic effect of the released daunorubicin hydrochlorideon HeLa and glioma cells (U87) in vitro. The inhibition ratios of HeLa and glioma cells followingtreatment with membranes prepared with 1, 5, and 10 wt% daunorubicin hydrochloride were 62.69%,76.12%, and 85.07% and 62.50%, 77.27%, and 84.66%, respectively. Therefore, PCL melt electrospun fibrousmembranes loaded with daunorubicin hydrochloride may be used in the local administration ofoncotherapy.

关 键 词：Melt electrospinning Drug delivery system Poly(ε-caprolactone) Daunorubicin hydrochloride Tumor therapy 

分 类 号：R73[医药卫生—肿瘤]