Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions  

作　　者：Hangqi Zhu Bing Zhang Nali Zhu Mingchun Li Qilin Yu 

机构地区：[1]Key Laboratory of Molecular Microbiology and Technology,Ministry of Education,Department of Microbiology,College of Life Sciences,Nankai University,Tianjin 300071,China [2]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China [3]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China

出　　处：《Chinese Chemical Letters》2021年第3期1220-1223,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.31870139);Natural Science Foundation of Tianjin(No.19JCZDJC33800);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-006);the Fundamental Research for the Central Universities。

摘　　要：In this study,we prepared mitochondrion targeting peptide-grafted magnetic graphene oxide(GO)nanocarriers for efficient impairment of the tumor mitochondria.The two-dimensional GOMNP-MitP nanosheets were synthesized by grafting magnetic y-Fe_(2)O_(3)to the surface of GO,followed by covalent modification of mitochondrion targeting peptide(MitP).GOMNP-MitP exhibited the high capacity of loading the anticancer drug mitoxantrone(MTX),and preferentially targeted the tumor mitochondria.With the aid of alternating magnetic field(AMF),the MTX-loading GOMNP-MitP released MTX to the mitochondria,severely impairing mitochondrial functions,including attenuation of ATP production,decrease in mitochondrial membrane potential(MMP),and further leading to activation of apoptosis.This study realized high-efficient mitochondrion-ta rgeting drug delivery for anticancer therapy by twodimensional nanoplatforms.

关 键 词：Magnetic graphene oxide Nanocarrier Mitochondrion-targeting peptide MITOXANTRONE Cancer therapy 

分 类 号：TB383.4[一般工业技术—材料科学与工程] TQ460.4[化学工程—制药化工]