CAMPTOTHECIN

作品数：72被引量：129H指数：6
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相关作者：唐中华祖元刚于景华钟大放李柯更多>>
相关机构：东北林业大学沈阳药科大学华中科技大学中国科学院更多>>
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Rising above:exploring the therapeutic potential of natural product-based compounds in human cancer treatment
《Traditional Medicine Research》2025年第3期56-74,共19页Li-Yan Yang Shi-Zeng Lei Wen-Jing Xu Yu-Xin Lai Ying-Ying Zhang Ying Wang Zhong-Lei Wang 
supported by the National Natural Science Foundation of China(grant number 22309103);Natural Science Foundation of Shandong Province(grant numbers ZR2022MH162,ZR2022QE202);PhD Research Start-up Foundation of Qufu Normal University(grant numbers 614901,615201);the project of introduction and cultivation for young innovation talents in the colleges and universities of Shandong Province(grant number 614202).
Tumors,due to their diversity and heterogeneity,pose a significant threat to human health.Multidrug resistance is a prevalent and grave issue in clinical treatment,resulting in treatment failure and cancer recurrence....
关键词：TUMORS multidrug resistance natural products CAMPTOTHECIN future challenges 
Shape effect of prodrug nanoassemblies on treatment efficacy of cancer therapy
《Nano Research》2025年第2期616-626,共11页Fengxiang Liu Rongzheng Liu Xiaoyuan Fan Xia Wang Kaiyuan Wang Hainan Zhao Hao Ye Shunzhe Zheng Xiao Kuang Yinxian Yang Haotian Zhang Qiming Kan Zhonggui He Jian Chen Jin Sun 
This research was supported by National Natural Science Foundation of China(Nos.82273874 and 82404561);Liaoning Revitalization Talents Program(No.XLYC22202019);the China National Postdoctoral Program for Innovative Talents(No.BX20240233);the Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(No.GZB20240179);the China Postdoctoral Science Foundation(No.2023MD744230);Doctoral Scientific Research Launching Fund Project of Liaoning province(No.2024-BS-075);Prospective Basic research project of 2024 Scientific Research Project of Liaoning Department of Education(No.LJ212410163042).
The tumor microenvironment-sensitive prodrug-based nanoparticles(NPs)have emerged as a promising drug delivery system(DDS).The shape of these particles plays a crucial role in their in vivo behavior.However,non-spheri...
关键词：CAMPTOTHECIN SELF-ASSEMBLY prodrug-based nanoparticles nanorod cancer therapy 
The role of hydrogen bonding in solubilizing camptothecin in hydrophilic and hydrophobic ionic liquids
《Green Chemical Engineering》2024年第4期489-500,共12页Xiaotong Zhu Liwen Mu Jiahua Zhu Xiaohua Lu Yuanhui Ji 
supported by the National Natural Science Foundation of China(Grant Nos.:22278070,21978047)
Utilizing ionic liquid(IL)-water mixtures as selective extraction solvents for raw materials from natural sources represents an efficacious approach;however,elucidating the underlying mechanisms inherent in various ty...
关键词：Ionic liquids Hydrogen bonding Molecular dynamics simulation Phase separation Quantum chemistry calculations 
Camptothecin multifunctional nanoparticles effectively achieve a balance between the efficacy of breast cancer treatment and the preservation of intestinal homeostasis
《Bioactive Materials》2024年第11期413-426,共14页Qingya Liu Yun Yang Meng Pan Kun Shi Dong Mo Yicong Li Meng Wang Linfeng Guo Zhiyong Qian 
National Natural Science Foundation of China Regional Innovation and Development Joint Fund(NSFCU21A20417);National Natural Science Foundation of China(NSFC31930067,NSFC32001003,NSFC82202320);Natural Science Foundation of Sichuan Province(2022NSFSC1282);135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18002);We also thank the support by Post-Doctor Research Project,West China Hospital,Sichuan University(2023HXBH011,19HXBH099);Postdoctoral Interdisciplinary Innovation Foundation Project of Sichuan University(1082204112G23);China Postdoctoral Science Foundation(2023M742476);Natural Science Foundation of Sichuan Province(2023NSFSC1585).
Camptothecin(CPT)exhibits potent antitumor activity;however,its clinical application is limited by significant gastrointestinal adverse effects(GAEs).Although the severity of GAEs associated with CPT derivatives has d...
关键词：CAMPTOTHECIN PCRHNs Intestinal barrier Intestinal microbiota PROBIOTICS 
Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin in Ophiorrhiza pumila被引量：1
《Journal of Integrative Plant Biology》2024年第6期1044-1047,共4页Tong Zhang Yan Wang Shiwen Wu Ernuo Tian Chengshuai Yang Zhihua Zhou Xing Yan Pingping Wang 
supported financially by the National Key Research and Development Program of China(Grant No.2018YFA0900700);the National Natural Science Foundation of China(Nos.31901021;31921006);the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences(Grant No.KFJ-BRP009)。
Camptothecin is one of the most commonly used anticancer drugs worldwide,yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.Here,we searched for ...
关键词：CAMPTOTHECIN STRICT DRUGS 
Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa
《Journal of Integrative Plant Biology》2024年第6期1158-1169,共12页Yin Chen Jian-Ping Huang Yong-Jiang Wang Meng-Ling Tu Junheng Li Bingyan Xu Guoqing Peng Jing Yang Sheng-Xiong Huang 
supported by National Natural Science Foundation of China(82225043);Biological Resources Program(KFJBRP-009);Yunnan Revitalization Talent Support Program“Yunling Scholar”Project(S.-X.H.);Yunnan Revitalization Talent Support Program“Young Talent”Project(J.-P.H.)。
Camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor activity.Given that two C-10 modified camptothecin derivatives,topotecan and irinotecan,have been approved as potent anticancer agents,...
关键词：camptothecin biosynthesis enzymatic assay Nothapodytes tomentosa tailoring enzyme transcriptomic analysis 
Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy
《Asian Journal of Pharmaceutical Sciences》2024年第1期135-146,共12页Sujie Huang Yuxuan Gao Ling Ma Bo Jia Wenhao Zhao Yufan Yao Wenyuan Li Tongyi Lin Rui Wang Jingjing Song Wei Zhang 
supported by the grants from the National Natural Science Foundation of China(Nos.81773566 and 21602092);Innovation Project of Medicine and Health Science and Technology of Chinese Academy of Medical Sciences(2019-I2M-5-074);the Funds for Fundamental Research Creative Groups of Gansu Province(No.20JR5RA310);the Fundamental Research Funds for the Central Universities(No.lzujbky-2021-38).
Melittin,a classical antimicrobial peptide,is a highly potent antitumor agent.However,its significant toxicity seriously hampers its application in tumor therapy.In this study,we developed novel melittin analogs with ...
关键词：Antimicrobial peptide Peptide-drug conjugate Cell-penetrating activity Membrane disruption Antitumor activity 
Solvent-mediated handedness inversed and amplified circularly polarized luminescence system based on camptothecin derivative
《Chinese Chemical Letters》2023年第2期188-192,共5页Xuan Wu Ming Liu Cheng Zheng Yingying Wang Yujing Zheng Yuna Qian Zhiyong Liao Guoyong Fang Jianliang Shen 
the National Natural Science Foundation of China (No. 22101280);Wenzhou Medical University (No. KYYW201901);University of Chinese Academy of Science (Nos. WIBEZD201700103 and WIUCASQD2020005);Zhejiang Provincial Natural Science Foundation (No. LQ20B020009) for financial support。
To realize the handedness controllable circularly polarized luminescence(CPL) system remains challenging. Herein, the solvent-mediated CPL inversion and amplification systems were successfully constructed by camptothe...
关键词：Circularly polarized luminescence Chirality inversion and amplification Solvent-incorporated self-assembly Camptothecin derivative Stimuli-responsiveness 
Linear-like polypeptide-based micelle with pH-sensitive detachable PEG to deliver dimeric camptothecin for cancer therapy
《Asian Journal of Pharmaceutical Sciences》2023年第1期97-107,共11页Ka Hong Wong Zhaopei Guo Di Jiang Xingzhi Zhou Lizhu Lin Denggao Zhao Meiwan Chen 
supported by the National Natural Science Foundation of China (51922111);the Science and Technology Development Fund, Macao SAR (File no. 0124/2019/A3);the University of Macao (File no. MYRG2022-00203-ICMS);Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials (2019B121205002)
Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).However,many challenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,a...
关键词：Dimeric camptothecin PH-SENSITIVE Redox-responsive Cancer therapy Self-assembled micelle 
OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila被引量：3
《Journal of Integrative Plant Biology》2023年第1期133-149,共17页Xiaolong Hao Can Wang Wei Zhou Qingyan Ruan Chenhong Xie Yinkai Yang Chengyu Xiao Yan Cai Jingyi Wang Yao Wang Xuebin Zhang Itay Maoz Guoyin Kai 
supported by the Major Science and Technology Projects of Breeding New Varieties of Agriculture in Zhejiang Province (2021C02074);National Natural Science Foundation of China (82003889, 31571735, 82073963, 81522049);National Key Research and Development Program of China (2018YFC1706203);Zhejiang Provincial Natural Science Foundation of China (LQ21H280004, LY20H280008);Zhejiang Provincial Ten Thousands Program for Leading Talents of Science and Technology Innovation (2018R52050);Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents;Research Project of Zhejiang Chinese Medical University (2021JKZDZC06);Opening Project of Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine (2021E10013)。
Camptothecin(CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. O...
关键词：camptothecin biosynthesis metabolic engineering strategies Ophiorrhiza pumila plant secondary metabolism transcriptional regulation 
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