Rising above:exploring the therapeutic potential of natural product-based compounds in human cancer treatment  

作　　者：Li-Yan Yang Shi-Zeng Lei Wen-Jing Xu Yu-Xin Lai Ying-Ying Zhang Ying Wang Zhong-Lei Wang 

机构地区：[1]School of Physics and Physical Engineering,Qufu Normal University,Qufu 273165,China [2]Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [3]Key Laboratory of Green Natural Products and Pharmaceutical Intermediates in Colleges and Universities of Shandong Province,School of Chemistry and Chemical Engineering,Qufu Normal University,Qufu 273165,China [4]School of Pharmaceutical Sciences,Key Laboratory of Bioorganic Phosphorus,Chemistry and Chemical Biology(Ministry of Education),Tsinghua University,Beijing 100084,China

出　　处：《Traditional Medicine Research》2025年第3期56-74,共19页TMR传统医学研究

基　　金：supported by the National Natural Science Foundation of China(grant number 22309103);Natural Science Foundation of Shandong Province(grant numbers ZR2022MH162,ZR2022QE202);PhD Research Start-up Foundation of Qufu Normal University(grant numbers 614901,615201);the project of introduction and cultivation for young innovation talents in the colleges and universities of Shandong Province(grant number 614202).

摘　　要：Tumors,due to their diversity and heterogeneity,pose a significant threat to human health.Multidrug resistance is a prevalent and grave issue in clinical treatment,resulting in treatment failure and cancer recurrence.This resistance renders conventional drug therapies ineffective,presenting a substantial challenge to human health and medical care.Exploring natural products as potential sources for anti-cancer drugs could lead to the development of innovative and efficacious cancer treatments.This article aims to investigate the health implications of natural products(such as paclitaxel,podophyllotoxin,homoharringtonine,camptothecin,and vinblastine)in the discovery of anti-cancer drugs while discussing the methods and progress made in researching novel anti-cancer drugs derived from natural products.The paper discusses the diversity,intricate structures,and target affinity of natural products along with their structural modification techniques,combination therapies utilization possibilities with prodrugs or nanoparticles.Additionally,considering the escalating multidrug resistance observed in tumors nowadays;certain natural products offer new insights and approaches for discovering effective anti-tumor drugs that are crucial for addressing global public health challenges.The challenges faced by natural products during drug development including issues related to bioavailability toxicity concerns as well as limited resources are examined thoroughly.Potential opportunities current issues along with future challenges are highlighted aiming at facilitating the clinical translation of original anti-cancer drugs using natural products.

关 键 词：TUMORS multidrug resistance natural products CAMPTOTHECIN future challenges 

分 类 号：R73[医药卫生—肿瘤]