Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin in Ophiorrhiza pumila  

作　　者：Tong Zhang Yan Wang Shiwen Wu Ernuo Tian Chengshuai Yang Zhihua Zhou Xing Yan Pingping Wang 

机构地区：[1]CAS‐Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular,Plant Sciences,Chinese Academy of Sciences,Shanghai 200032,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Integrative Plant Biology》2024年第6期1044-1047,共4页植物学报（英文版）

基　　金：supported financially by the National Key Research and Development Program of China(Grant No.2018YFA0900700);the National Natural Science Foundation of China(Nos.31901021;31921006);the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences(Grant No.KFJ-BRP009)。

摘　　要：Camptothecin is one of the most commonly used anticancer drugs worldwide,yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.Here,we searched for proteins involved in camptothecin biosynthesis from the camptothecin-producing plant Ophiorrhiza pumila by chemoproteomics and identified Op CYP716E111.

关 键 词：CAMPTOTHECIN STRICT DRUGS 

分 类 号：S567.19[农业科学—中草药栽培]