supported by the BK21 FOUR(Fostering Outstanding Universities for Research);the Basic Science Research Program through the National Research Foundation of Korea(NRF);the Regional Innovation Mega Project Program through the Korea Innovation Foundation funded by the Ministry of Education(MOE);the Ministry of Science and ICT(MSIT)(NRF-2022R1A2C1004204,RS-2023-00219563,2023-DD-UP-0007);the Soonchunhyang University Research Fund(to KK)。
Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal cord.This leads to muscle weakness,paralysis,and ul...
Background:Platinum-based chemotherapy in addition to the nonplatinum agent etoposide is the standard of care for extensive-stage small cell lung cancer(ES-SCLC).However,the front-line chemotherapy regimen is not know...
funded by the Optimization Study of Treatment Regimen and Clinical Practice in Ovarian Cancer(grant number:2016YFC1303702).
Background:The paclitaxel liposome formulation,encapsulating paclitaxel within a phospholipid bilayer,ad-dresses the insolubility of traditional paclitaxel formulations,thereby reducing toxicity without compromising i...
Understanding the prevalent form of platinum(Pt)based antineoplastic agents,used in chemotherapy,is of importance to develop a remediation strategy that restricts aquatic exposure.The speciation of Pt-based compounds ...
BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature.Breast metastases are associated with poor prognosis.The following case highlights the dia...
Supported by the Foundation of Science and Technology Bureau of Dalian,No. 2021JJ13SN70。
BACKGROUND Combined small cell lung cancer(C-SCLC) is a special subtype of small cell lung cancer that is relatively rare, aggressive, and prone to early metastasis and has a poor prognosis. Currently, there are limit...
This work was supported by the grant from the National Natural Science Foundation of China(No.21672225).
Despite favorable responses to platinum-based chemotherapy in ovarian cancer(OC),chemoresistance is still a major cause of treatment failure.Hence,we develop a novel synthetic agent,COM33,to relieve the chemoresistanc...
Ovarian cancer is one of the most lethal gynecologic cancers.The standard therapy for ovarian cancer has been the same for the past two decades,a combination treatment of platinum with paclitaxel.Recently,the FDA appr...
Patients with non-small cell lung cancer (NSCLC) who have received more than one cycle of platinum-based chemotherapy in their lifetime may be at risk of hypersensitivity. The overall incidence of hypersensitivity to ...
This work was supported by a grant from the National Natural Science Foundation of China(Nos.81773652 and 81974498);the Young Scholar Program of Shandong University(2017WLJH40).
To improve therapeutic effect and reduce severely side effects of carboplatin(CBP),the gas-generating nanocapsules were developed to accelerate CBP lysosome release and nucleus delivery.CBP/SB-NC was prepared by co-lo...