Ce6 nanoassemblies:Molecular mechanism and strategies for combinational anticancer therapy Special Collection:Aggregation-Induced Processes and Functions  

作　　者：Yuwei Liu Shuting Xu Qingyang Lyu Yi Huang Weiping Wang 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,The University of Hong Kong,Hong Kong,China [2]Department of Pharmacology and Pharmacy,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China [3]Laboratory of Molecular Engineering and Nanomedicine,Dr.Li Dak-Sum Research Centre,The University of Hong Kong,Hong Kong,China

出　　处：《Aggregate》2024年第1期130-147,共18页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:82222903;Li Ka Shing Faculty of Medicine(Start-up Fund)of The University of Hong Kong.

摘　　要：Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety profile.However,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor microenvironment.To overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic activity.This review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional molecules.The self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.

关 键 词：cancer treatment carrier-free chlorin e6(Ce6) light NANOMEDICINE photodynamic therapy(PDT) SELFASSEMBLY 

分 类 号：R730.5[医药卫生—肿瘤]