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ICH: 作品数：744被引量：1751H指数：18; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：邹伟洪小栩王珑姚晨陈英更多>>; 相关机构：国家食品药品监督管理局药品审评中心中国药科大学中国药品生物制品检定所沈阳药科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家科技重大专项中国博士后科学基金更多>>

Towards mechanism-based tau-targeted therapies: 《Neural Regeneration Research》2026年第2期687-688,共2页Lidia Bakota Roland Brandt; Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...; 关键词：tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively

In Situ Partial-Cyclized Polymerized Acrylonitrile-Coated NCM811 Cathode for High-Temperature≥100℃ Stable Solid-State Lithium Metal Batteries: 《Nano-Micro Letters》2025年第8期399-415,共17页Jiayi Zheng Haolong Jiang Xieyu Xu Jie Zhao Xia Ma Weiwei Sun Shuangke Liu Wei Xie Yufang Chen ShiZhao Xiong Hui Wang Kai Xie Yu Han Maoyi Yi Chunman Zheng Qingpeng Guo; financially supported by the National Natural Science Foundation of China(Nos.22102212 and 22479067).; High-nickel ternary cathodes hold a great application prospect in solid-state lithium metal batteries to achieve high-energy density,but they still suffer from structural instability and detrimental side reactions wit...; 关键词：Solid-state lithium metal battery Ni-rich cathode Interface engineering In situ partial-cyclized PAN High-temperature resistance

Chinese Cloisonne: 《China Today》2025年第5期80-80,共1页; CHINESE Cloisonneis the centuries-old handicraft of creating designs on copper bodies with colored-enamel placed within divisions made of copper wires,which are bent to follow the outline of decorative patterns.This f...; 关键词：arab world copper wires copper wireswhich colored enamel centuries old handicraft chinese cloisonneis decorative patterns creating designs copper bodies

Correction:Defects-Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption: 《Nano-Micro Letters》2025年第4期290-290,共1页Jiaolong Liu Siyu Zhang Dan Qu Xuejiao Zhou Moxuan Yin Chenxuan Wang Xuelin Zhang Sichen Li Peijun Zhang Yuqi Zhou Kai Tao Mengyang Li Bing Wei Hongjing Wu; Correction to:Nano-Micro Lett.(2025)17:24 https://doi.org/10.1007/s40820-024-01515-0 Following publication of the original article[1],the authors reported the author list needed to be updated because the last three au...; 关键词：STRONG Polarization Defects

Enhancing Structural Stability and Electrochemical Performance of Ultra-high Ni-rich Co-free Cathode via MgHPO_(4) Dual-functional Modification: 《Chemical Research in Chinese Universities》2025年第2期333-342,共10页LIN Huahui SHEN Yu WEI Li SONG Ran WU Fan WEI Peng YANG Zhenzhong REN Yurong QU Ke DING Zhengping; supported by the National Natural Science Foundation of China(Nos.52203291,U22A20420,52202235).; Ultra-high nickel layered cathodes(Ni≥95%)have emerged as prospective candidates for next-generation lithium-ion batteries(LIBs)due to their exceptional specific capacity and cost-effectiveness.However,the commercial...; 关键词：Lithium-ion battery Ni-rich Co-free cathode MgHPO_(4) Surface modification

ICH M7方法4在基因毒性杂质控制中的应用: 《山东化工》2025年第5期220-222,225,共4页潘昭喜; 基因毒性杂质是药物申报中重点关注的部分,因其限度往往很低,药物研发过程中增加基因毒性杂质的研究将严重增加研发成本。ICH M7为控制(潜在)基因毒性杂质提供了一系列灵活的方法,其中包括方法4,它利用现有的过程知识和/或数据来证明控...; 关键词：预测清除因子基因毒性杂质控制 ICH M7方法4

Electrolyte engineering and interphase chemistry toward high-performance nickel-rich cathodes:Progress and perspectives: 《Materials Reports(Energy)》2025年第1期19-31,共13页Shangjuan Yang Ke Yang Jinshuo Mi Shaoke Guo Xufei An Hai Su Yanbing He; supported by the National Key Research and Development Program of China(2021YFF0500600);National Natural Science Foundation of China(Nos.U2001220,52203298 and 523B2022);National Science Fund for Distinguished Young Scholars(No.52325206);Shenzhen Technical Plan Project(Nos.RCJC20200714114436091,JCYJ20220530143012027,JCYJ20220818101003008 and JCYJ20220818101003007);Tsinghua Shenzhen International Graduate School-Shenzhen Pengrui Young Faculty Program of Shenzhen Pengrui Foundation(No.SZPR2023006).; Nickel(Ni)-rich layered oxides have drawn great attention as cathode for lithium batteries due to their high capacity,high working voltage and competitive cost.Unfortunately,the operation of Ni-rich cathodes suffers f...; 关键词：Ni-rich cathodes Solvation structure regulation Electrolyte additives Cathode-electrolyte interphase High charging cut-off voltage

Insights into the doping functions on redox chemistry of layered Ni-rich cathodes: 《Journal of Energy Chemistry》2025年第3期386-412,共27页Zhenxing Wang Yong Chen; supported by the National Natural Science Foundation of China(22209055);the China Postdoctoral Science Foundation(2022M721330);the Foshan Postdoctoral Science Foundation(X221081MS210);the Innovation Team of Universities of Guangdong Province(2022KCXTD030);the“Targeted Technology Innovation Initiative”Project at the Foshan National Institute of Innovation(JBGS2024002)。; In pursuit of low cost and long life for lithium-ion batteries in electric vehicles,the most promising strategy is to replace the commercial LiCoO_(2)with a high-energy-density Ni-rich cathode.However,the irreversible...; 关键词：Doping functions Redox chemistry Ni-rich cathode Phase transition Structural stability

Unveiling the effect of molybdenum and titanium co-doping on degradation and electrochemical performance in Ni-rich cathodes: 《Materials Reports(Energy)》2025年第1期32-42,共11页Imesha Rambukwella Konstantin L.Firestein Yanan Xu Ziqi Sun Shanqing Zhang Cheng Yan; support from Queensland University of Technology,Brisbane,Queensland,Australia;financial support from ARC Discovery Project(DP210103266).; In this work,we have applied molybdenum(Mo)and titanium(Ti)co-doping to solve the degradation of Ni-rich cathodes.The modified cathode,i.e.,Li(Ni_(0.89)Co_(0.05)Mn_(0.05)Mo_(0.005)Ti_(0.005))O_(2) holds a stable struc...; 关键词：Ni-rich cathode Mo doping Ti doping DEGRADATION Unsymmetrical phase transition Mechanical stress Particle cracking

生物技术产品病毒安全控制技术要求发展趋势研究以ICH Q5A(R2)为例: 《中国新药杂志》2025年第6期566-570,共5页赛文博于鹏丽韦薇; ICH Q5A(R1)《来源于人或动物细胞系生物技术产品的病毒安全性评价》是针对特定生物技术产品病毒安全控制的专项指导原则,对于重组蛋白、基因工程病毒载体等多种药品的研发和生产具有重要的指导意义。该指导原则自1999年开始正式实施,...; 关键词：病毒安全控制生物技术产品下一代测序先验知识病毒清除工艺连续制造

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