Towards mechanism-based tau-targeted therapies  

作　　者：Lidia Bakota Roland Brandt 

机构地区：[1]Department of Neurobiology,School of Biology/Chemistry,Osnabrück University,Osnabrück,Germany [2]Center for Cellular Nanoanalytics,Osnabrück University,Osnabrück,Germany [3]Institute of Cognitive Science,Osnabrück University,Osnabrück,Germany

出　　处：《Neural Regeneration Research》2026年第2期687-688,共2页中国神经再生研究(英文版)

摘　　要：Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,tau is not an easy target because it dynamically interacts with microtubules and other cellular components,which presents a challenge for tau-targeted drugs.New cellular models could aid the development of mechanism-based tau-targeted therapies.

关 键 词：tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively 

分 类 号：R741[医药卫生—神经病学与精神病学]