Mesenchymal stem cells’“garbage bags”at work:Treating radial nerve injury with mesenchymal stem cell-derived exosomes  

作　　者：Mazhar Mushtaq Doaa Hussein Zineldeen Muhammad Abdul Mateen Khawaja Husnain Haider 

机构地区：[1]Department of Basic Sciences,Sulaiman AlRajhi University,Albukairiyah 52736,AlQaseem,Saudi Arabia [2]Medical Biochemistry and Molecular Biology Department,Faculty of Medicine,Tanta University,Tanta 6632110,Egypt

出　　处：《World Journal of Stem Cells》2024年第5期467-478,共12页世界干细胞杂志（英文版）（电子版）

摘　　要：Unlike central nervous system injuries,peripheral nerve injuries(PNIs)are often characterized by more or less successful axonal regeneration.However,structural and functional recovery is a senile process involving multifaceted cellular and molecular processes.The contemporary treatment options are limited,with surgical intervention as the gold-standard method;however,each treatment option has its associated limitations,especially when the injury is severe with a large gap.Recent advancements in cell-based therapy and cell-free therapy approaches using stem cell-derived soluble and insoluble components of the cell secretome are fast-emerging therapeutic approaches to treating acute and chronic PNI.The recent pilot study is a leap forward in the field,which is expected to pave the way for more enormous,systematic,and well-designed clinical trials to assess the therapeutic efficacy of mesenchymal stem cell-derived exosomes as a bio-drug either alone or as part of a combinatorial approach,in an attempt synergize the best of novel treatment approaches to address the complexity of the neural repair and regeneration.

关 键 词：EXOSOME Mesenchymal stem cells Nerve injury Stem cells SECRETOME Regeneration 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]