Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies  

作　　者：Francesco Ferrini Esri H.Juárez Adalberto Merighi 

机构地区：[1]Department of Veterinary Sciences,University of Turin,Grugliasco,TO,Italy [2]Department of Psychiatry and Neuroscience,UniversitéLaval,Québec City,QC,Canada

出　　处：《Neural Regeneration Research》2025年第1期181-183,共3页中国神经再生研究（英文版）

基　　金：supported by the National Centre for the Replacement Refinement & Reduction of Animals in Research Crack It solution “Neuroinflammation and nociception in a dish”(https://nc3rs.org.uk/crackit/news/new-solutionneuroinflammation-and-nociception-dish) fund(to AM)。

摘　　要：Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical cord.MSCs have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue repair.MSCs enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC secretome.An increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关 键 词：protective clinical COLLECTIVE 

分 类 号：R741[医药卫生—神经病学与精神病学]