云南高校图书馆联盟文献共享服务平台- CHAPERONES

CHAPERONES: 作品数：24被引量：52H指数：5; 导出分析报告; 相关领域：生物学更多>>; 相关作者：丁伟柯莎周筠梅连惠勇更多>>; 相关机构：中国科学院更多>>; 相关期刊：《Chinese Journal of Polymer Science》《Genes & Diseases》《World Journal of Hepatology》《Neural Regeneration Research》更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>

Temperature-sensitive Micelles as Artificial Chaperones for Insulin Protection: 《Chinese Journal of Polymer Science》2025年第2期350-359,共10页Jia-Wen Chen Yan Xiao Mei-Dong Lang; financially supported by the National Natural Science Foundation of China(Nos.52273009 and 21674037).; Insulin is an essential and versatile protein taking part in the control of blood glucose levels and protein anabolism.However,under prolonged storage or high temperature stress,insulin tends to unfold and aggregate i...; 关键词：TEMPERATURE-SENSITIVE INSULIN Micelles CHAPERONES

Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration: 《Neural Regeneration Research》2023年第4期769-772,共4页Sandeep Satapathy Mark R.Wilson; Protein quality control involves many processes that jointly act to regulate the expression, localization, turnover, and degradation of proteins, and has been highlighted in recent studies as critical to the different...; 关键词：cell viability CLUSTERIN extracellular chaperones inflammation NEUROSERPIN protein misfolding TRANSTHYRETIN Α2-MACROGLOBULIN

Chaperone-assisted E3 ligase CHIP:A double agent in cancer: 《Genes & Diseases》2022年第6期1521-1555,共35页Sunny Kumar Malini Basu Mrinal K.Ghosh; This work is jointly supported by the Department of Science and Technology(NanoMission:DST/NM/NT/2018/105(G);SERB:EMR/2017/000992);HCT-Focused Basic Research(FBR),(Sanction No.31-2(274)2020-21/Bud-II,dated-03.03.2021),CSIR,Govt.of India.; The carboxy-terminus of Hsp70-interacting protein(CHIP)is a ubiquitin ligase and co-chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular homeostasis by switching the equilibrium ...; 关键词：Chaperones(HSC70/HSP70&HSP90) CHIP ONCOGENE Therapy Tumor suppressor Ubiquitin proteasome system(UPS)

Neural functions of small heat shock proteins被引量：1: 《Neural Regeneration Research》2022年第3期512-515,共4页Teresa de los Reyes Sergio Casas-Tintó; Stress response is a cellular widespread mechanism encoded by a common protein program composed by multiple cellular factors that converge in a defense reaction to protect the cell against damage.Among many mechanisms...; 关键词：AGING central nervous system CHAPERONES environment NEUROPROTECTION PATHOLOGY stress synapses

Improved pinene production in a recombinant yeast by fusion linker optimization and chaperon coexpression被引量：1: 《Systems Microbiology and Biomanufacturing》2022年第1期208-216,共9页Quanlu Ren Yaxi He Xinyao Lu Hong Zong Bin Zhuge; This work was supported by the National Natural Science Foundation of China(No.31970033).; Pinene is an active natural monoterpene from plants and has important applications in favorings,fragrances,and pesticides.Especially,pinene dimers are regarded as renewable fuels with high density.However,the microbia...; 关键词：PINENE Saccharomyces cerevisiae Fusion protein Oligopeptide linker CHAPERONES

A small molecule UPR modulator for diabetes identified by high throughput screening被引量：2: 《Acta Pharmaceutica Sinica B》2021年第12期3983-3993,共11页Valeria Marrocco Tuan Tran Siying Zhu Seung Hyuk Choi Ana M.Gamo Sijia Li Qiangwei Fu Marta Diez Cunado Jason Roland Mitch Hull Van Nguyen-Tran Sean Joseph Arnab K.Chatterjee Nikki Rogers Matthew S.Tremblay Weijun Shen; supported by the Juvenile Diabetes Research Foundation (JDRF) [3-PAR-2016-241-I-X, US]。; Unfolded protein response(UPR) is a stress response that is specific to the endoplasmic reticulum(ER).UPR is activated upon accumulation of unfolded(or misfolded) proteins in the ER's lumen to restore protein folding ...; 关键词：βcells Unfolded protein response Small molecules Protein folding Endoplasmic reticulum CHAPERONES Cell signaling DIABETES ER stress Liver PANCREAS Metabolic diseases

Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases被引量：4: 《Acta Pharmaceutica Sinica B》2021年第10期2995-3014,共20页Arun Upadhyay; Cells have different sets of molecules for performing an array of physiological functions.Nucleic acids have stored and carried the information throughout evolution,whereas proteins have been attributed to performing ...; 关键词：PROTEOSTASIS Proteinopathies CHAPERONES Ubiquitin proteasome system AUTOPHAGY Cancer NEURODEGENERATION Ageing Natural molecules Drug discovery

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation被引量：4: 《Cell Research》2021年第9期1024-1027,共4页Jinge Gu Chen Wang Rirong Hu Yichen Li Shengnan Zhang Yunpeng Sun Qiangqiang Wanq Dan Li Yanshan Fang Cong Liu; Dear Editor,TAR DNA-binding protein 43 kDa(TDP-43)undergoes liquid-liquid phase separation(LLPS)and forms reversible,cytoprotective nuclear bodies(NBs)under stress.1 Abnormal liquid-to-solid phase transition condenses...; 关键词：protective DEGENERATION AMYLOID

Protein quality control of cell stemness被引量：5: 《Cell Regeneration》2020年第1期259-269,共11页Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu; This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100);the National Key Research and Development Program of China(2018YFC2000100);the National Natural Science Foundation of China(81625009,81921006,81822018).; Protein quality control(PQC)systems play essential roles in the recognition,refolding and clearance of aberrant proteins,thus ensuring cellular protein homeostasis,or proteostasis.Especially,continued proliferation an...; 关键词：Protein quality control Stem cells STEMNESS CHAPERONES Unfolded protein response Ubiquitinproteasome system AUTOPHAGY

Mechanisms of Chaperones as Active Assistant/Protector for Proteins:Insights from NMR Studies: 《Chinese Journal of Chemistry》2020年第4期406-413,共8页Yunfei Hu Conggang Li Lichun He Changwen Jin Maili Liu; This work is supported by grants from the National Key R&D Program of China(Nos.2018YFA0704002,2018YFE0202300,2017YFA0505400);the Natlonal Natural sclence Foundatlon uf China(Nos.21735007,21675170,21475146,31370718);the Chinese Academy of Sciences(No.QYZDJ-SSW-SLH027).; Molecular chaperones are diverse families of proteins that play key roles in protein homeostasis.They assist the folding of client proteins or prevent them from rreversible aggregation under stress conditions.Diverse ...; 关键词：CLIENT ACTIVE HOMEOSTASIS

CHAPERONES