Protein quality control of cell stemness  

作　　者：Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu 

机构地区：[1]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]China National Center for Bioinformation,Beijing 100101,China [4]CAS Key Laboratory of Genomic and Precision Medicine,Collaborative Innovation Center of Genetics and Development,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China [5]Institute for Stem cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [6]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [7]Beijing Institute for Brain Disorders,Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital Capital Medical University,Beijing 100053,China.

出　　处：《Cell Regeneration》2020年第1期259-269,共11页细胞再生（英文）

基　　金：This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100);the National Key Research and Development Program of China(2018YFC2000100);the National Natural Science Foundation of China(81625009,81921006,81822018).

摘　　要：Protein quality control(PQC)systems play essential roles in the recognition,refolding and clearance of aberrant proteins,thus ensuring cellular protein homeostasis,or proteostasis.Especially,continued proliferation and differentiation of stem cells require a high rate of translation;therefore,accurate PQC systems are essential to maintain stem cell function.Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells.This review focuses on current knowledge regarding the components of the proteostasis network in stem cells,and the importance of proteostasis in maintaining stem cell identity and regenerative functions.A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases.

关 键 词：Protein quality control Stem cells STEMNESS CHAPERONES Unfolded protein response Ubiquitinproteasome system AUTOPHAGY 

分 类 号：R73[医药卫生—肿瘤]