Mechanisms of Chaperones as Active Assistant/Protector for Proteins:Insights from NMR Studies  

作　　者：Yunfei Hu Conggang Li Lichun He Changwen Jin Maili Liu 

机构地区：[1]State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan National Laboratory for Optoelectronics,National Center for Magnetic Resonance in Wuhan,Key Laboratory of Magnetic Resonance in Biological Systems,Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences[CAS],Wuhan,Hubei 430071,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Beijing Nuclear Magnetic Resonance Center,College of Chemistry and Molecular Engineering,College of Life Sciences,Peking University,Beijing 100871,China

出　　处：《Chinese Journal of Chemistry》2020年第4期406-413,共8页中国化学（英文版）

基　　金：This work is supported by grants from the National Key R&D Program of China(Nos.2018YFA0704002,2018YFE0202300,2017YFA0505400);the Natlonal Natural sclence Foundatlon uf China(Nos.21735007,21675170,21475146,31370718);the Chinese Academy of Sciences(No.QYZDJ-SSW-SLH027).

摘　　要：Molecular chaperones are diverse families of proteins that play key roles in protein homeostasis.They assist the folding of client proteins or prevent them from rreversible aggregation under stress conditions.Diverse chaper-one families contribute to different aspects of protein homeostasis by inter-acting with a wide range of client proteins.Despite the vital roles of chaper-ones in cell survival,the molecular mechanisms underlying chaperone func-tions remain elusive,due to the non-specificity of chaperone-client interac-tions and the intrinsic flexibility of the clients.

关 键 词：CLIENT ACTIVE HOMEOSTASIS 

分 类 号：Q51[生物学—生物化学]