ONCOGENE

作品数：280被引量：766H指数：16
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相关领域：医药卫生生物学更多>>
相关作者：雷著斌李晓燕吴直江葛柏青朱铭伟更多>>
相关机构：第二军医大学北京大学中国科学院济南军区总医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划国家教育部博士点基金更多>>
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Correction: Silencing of the long non-coding RNA LINC00265triggers autophagy and apoptosis in lung cancer by reducingprotein stability of SIN3A oncogene
《Oncology Research》2025年第5期1249-1250,共2页XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU 
In the article“Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene”(Oncology Research.2024,Vol.32,No.7,pp.1185–1195.doi:10....
关键词：lung cancer long non coding RNA reducing protein stability sin oncogene oncology AUTOPHAGY protein stability APOPTOSIS accuracy integrity SILENCING 
A novel metabolite-interacting protein(MIP)-based molecular subtyping construction and validation of IGFBP3 as a MiP-related oncogene in colorectal cancer
《Genes & Diseases》2025年第2期7-10,共4页Simeng Bao Yongmin Li Yu Liang Jianxun Dai Huolin Huang Bin Ma 
supported by grants from the Cultivation Program of National Science Foundation of Liaoning Cancer Hospital (China) (No.2021-ZLLH-03);Beijing Xisike Clinical Oncology Research Foundation (China) (No.Y-QL202101-0039);Medical and Industrial Cross Joint Fund of Dalian University of Technology-Liaoning Cancer Hospital (China) (No.LD2023027);The National Natural Science Foundation of China (No.82303131);the Liaoning Province Science and Technology Plan Joint Program (Applied Basic Research Project) (China) (No.2023JH2/101700150).
For prognosis and therapeutic response,colorectal cancer(CRC)patients are highly variable across stages,correlated to high inter-tumor heterogeneity at the molecular level.1 Therefore,molecular subtyping needs to be d...
关键词：colorectal cancer IGFBP3 
TMEM33,an oncogene regulated by miR-214-3p,promotes the progression of lung adenocarcinoma through the Wnt/β-catenin signaling pathway
《Oncology Research》2025年第4期905-917,共13页GUANGXIAN YOU QIAO YANG XIN LI LILI CHEN 
Background:Lung cancer remains a major factor causing cancer-associated mortality globally.While there have been advancements in treatment options,advanced lung cancer patients still have poor outcomes.This study aims...
关键词：Lung adenocarcinoma(LUAD) Transmembrane protein 33(TMEM33) miR-214-3p Wingless(Wnt) Malignant progression 
Comprehensive Bioinformatics Analysis Reveals Kirsten Rat Sarcoma Virus Oncogene(KRAS)as the Potential Biomarker of Esophageal Carcinoma
《Proceedings of Anticancer Research》2024年第6期209-222,共14页Muhammad Akram 
In the current study, the expression of the Kirsten rat sarcoma virus oncogene (KRAS) in esophageal carcinoma (ESCA) was examined for its medical and therapeutic relevance. ESCA has a 20% five-year survival rate, plac...
关键词：KRAS ESCA Therapeutic BIOMARKER Bioinformatics 
Identification of MUC1 as a Novel Oncogene of Fusobacterium nucleatum-Associated Colorectal Cancer by a Combined Bioinformatics and Experimental Approach
《Journal of Cancer Therapy》2024年第10期362-380,共19页Xinli Ye Shouru Zhang Zhaoli Zhang Jie Zou Xiaojie Gao 
Background: Fusobacterium nucleatum can cause opportunistic and chronic infections and has recently been shown to be involved in colorectal cancer. However, the specific mechanism by which F. nucleatum induces colorect...
关键词：CRC F. nucleatum DEGs MUC1 
USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells
《Genes & Diseases》2024年第5期44-47,共4页Kai Li Qian Wang Hua Bian 
National Nature Science Foundation of China(No.82002592);the Doctoral Research Start-up Fund Project of Nanyang Institute of Technology of China.
Deubiquitinases(DUBs)are a class of enzymes that are able to reverse the process of ubiquitination.1 Extensive research has revealed that there are more than 100 DUBs found in humans,which are classified into seven ma...
关键词：ESOPHAGEAL cancer Zinc 
The role of tazarotene-induced gene 1 in carcinogenesis:is it a tumor suppressor gene or an oncogene?
《BIOCELL》2024年第9期1285-1297,共13页CHUN-HUA WANG LU-KAI WANG RONG-YAUN SHYU FU-MING TSAI 
supported by the Taipei Tzu Chi Hospital through grants from the Buddhist Tzu Chi Medical Foundation under the Numbers TCRD-TPE-111-23(2/3)and TCRD-TPE-113-20,Taipei,Taiwan.
Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer.TIG1 is widely expressed in various tissues;yet...
关键词：Tazarotene-induced gene 1 Retinoic acid receptor responder protein 1 Tumor suppressor gene ONCOGENE 
Immune status and combined immunotherapy progression in Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors
《Chinese Journal of Cancer Research》2024年第4期421-441,共21页Dongsheng He Rilan Bai Naifei Chen Jiuwei Cui 
supported by National Natural Science Foundation of China—Youth Fund Project (No.32000617);Jilin Provincial Science and Technology Department (No.20200602032ZP and No.20210 303002SF);Jilin Provincial Development and Reform Commission (No.2021C10);Changchun Science and Technology Bureau (No.21ZGY28)
Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most frequently mutated oncogene,occurring in various tumor types.Despite extensive efforts over the past 40 years to develop inhibitors targeting KRAS mutations,...
关键词：Cancer KRAS mutation targeted therapy IMMUNOTHERAPY immune microenvironment 
Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer
《Chinese Medical Journal》2024年第15期1844-1856,共13页Yue Ge Sheng Ma Qiang Zhou Zezhong Xiong Yanan Wang Le Li Zheng Chao Junbiao Zhang Tengfei Li Zixi Wu Yuan Gao Guanyu Qu Zirui Xi Bo Liu Xi Wu Zhihua Wang 
supported by the National Natural Science Foundation of China(Nos.82173068,81974400);the Applied Basic Research Plan from Qinghai Provincial Department of Science and Technology(No.2021-ZJ-723).
Background:Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer(PCa),the long tail of cancer genes remains to be defined.Goosecoid(GSC)has been implicated ...
关键词：GOOSECOID Prostate cancer Prognosis E2F transcription factor 1 Trametinib 
Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene
《Oncology Research》2024年第7期1185-1195,共11页XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU 
supported in part by the National Natural Science Foundation of China(NSFC)(82073388 to SWM);the Natural Outstanding Youth Fund of Guangdong Province(2022B1515020090 to SWM);Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases(2022B1212030003 to SWM);the Affiliated Hospital of Guangdong Medical University Clinical Research Program(LCYJ2020B005 to SWM).
Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes.Their dysregulation has been closely associated with tumorigenesis.LINC00265 is upreg...
关键词：LINC00265 AUTOPHAGY Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A) 
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