The role of tazarotene-induced gene 1 in carcinogenesis:is it a tumor suppressor gene or an oncogene?  

作　　者：CHUN-HUA WANG LU-KAI WANG RONG-YAUN SHYU FU-MING TSAI 

机构地区：[1]Department of Dermatology,Taipei Tzu Chi Hospital,Buddhist Tzu Chi Medical Foundation,New Taipei City,231,Taiwan,China [2]School of Medicine,Tzu Chi University,Hualien,970,Taiwan,China [3]Department of Life Sciences,Ministry of Science and Technology,Taipei,106,Taiwan,China [4]Department of Internal Medicine,Taipei Tzu Chi Hospital,The Buddhist Tzu Chi Medical Foundation,New Taipei City,231,Taiwan,China [5]Department of Research,Taipei Tzu Chi Hospital,Buddhist Tzu Chi Medical Foundation,New Taipei City,231,Taiwan,China

出　　处：《BIOCELL》2024年第9期1285-1297,共13页生物细胞（英文）

基　　金：supported by the Taipei Tzu Chi Hospital through grants from the Buddhist Tzu Chi Medical Foundation under the Numbers TCRD-TPE-111-23(2/3)and TCRD-TPE-113-20,Taipei,Taiwan.

摘　　要：Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer.TIG1 is widely expressed in various tissues;yet in many cancer tissues,it is not expressed because of the methylation of its promoter.Additionally,the expression of TIG1 in cancer cells inhibits their growth and invasion,suggesting that TIG1 acts as a tumor suppressor gene.However,in some cancers,poor prognosis is associated with TIG1 expression,indicating its protumor growth characteristics,especially in promoting the invasion of inflammatory breast cancer cells.This review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development,with the aim of understanding its various roles in cancer development.

关 键 词：Tazarotene-induced gene 1 Retinoic acid receptor responder protein 1 Tumor suppressor gene ONCOGENE 

分 类 号：R730.1[医药卫生—肿瘤]