SILENCING

作品数：268被引量：796H指数：13
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相关领域：医药卫生生物学更多>>
相关作者：彭琦周晓婴高建芹浦惠明戚存扣更多>>
相关机构：中山大学浙江大学江苏省农业科学院复旦大学更多>>
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Stress signaling caused by mitochondrial import malfunction can be terminated by SIFI:Importance of stress response silencing
《Neural Regeneration Research》2026年第2期673-674,共2页Grace Hohman Michael Shahid Mohamed A.Eldeeb 
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...
关键词：activation stress pathways neurodegenerative disorders protein aggregatesmitochondrial import stress stress signaling protein aggregates goiran protein aggregates protein aggr neurodegenerative diseasesincluding 
Correction: Silencing of the long non-coding RNA LINC00265triggers autophagy and apoptosis in lung cancer by reducingprotein stability of SIN3A oncogene
《Oncology Research》2025年第5期1249-1250,共2页XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU 
In the article“Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene”(Oncology Research.2024,Vol.32,No.7,pp.1185–1195.doi:10....
关键词：lung cancer long non coding RNA reducing protein stability sin oncogene oncology AUTOPHAGY protein stability APOPTOSIS accuracy integrity SILENCING 
RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis
《World Journal of Stem Cells》2025年第4期64-78,共15页Song-Guan Wei Hui-Hong Chen Liu-Rong Xie Yuan Qin Yu-Ying Mai Lin-Hui Huang Hong-Bing Liao 
Supported by the National Natural Science Foundation of China,No.82160192;and Guangxi Science and Technology Program,No.2023AB23037.
BACKGROUND In vivo degradation of bone scaffolds is significantly influenced by osteoclast(OC)activity,which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand(RANKL)and osteo...
关键词：OSTEOPROTEGERIN Receptor activator of nuclear factor-kappa B ligand Bone marrow-derived mesenchymal stem cells RNA interference OSTEOCLAST Bone scaffold 
NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway
《World Journal of Diabetes》2025年第3期203-215,共13页Jin-Meng Li Zi-Hua Song Yuan Li Han-Wen Chen Han Li Lu Yuan Jing Li Wen-Yue Lv Lei Liu Na Wang 
Supported by Research Fund for Academician Lin He New Medicine,No.JYHL2022FMS02.
BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed th...
关键词：Diabetes Diabetic kidney disease PYROPTOSIS FIBROSIS Nuclear receptor subfamily 4 group A member 1 
The biogenesis,regulation and functions of transitive siRNA in plants被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期131-147,共17页Huijun Tan Yuelin Liu Hongwei Guo 
supported by the grants from the National Natural Science Foundation of China(No.32261160572 to H.G.);the New Cornerstone Science Foundation(No.NCI202235 to H.G);Shenzhen Science and Technology Program(Nos.KQTD20190929173906742 and ZDSYS20230626091659010 to H.G.,JCYJ20190809163019421 to Y.L.);Shenzhen Branch,Guangdong Laboratory for Lingnan Modern Agriculture(to H.G.).
Small RNA(sRNA)-mediated RNA interference(RNAi)is a sequence-specific gene silencing mechanism that modulates gene expression in eukaryotes.As core molecules of RNAi,various sRNAs are encoded in the plant genome or de...
关键词：SILENCING SIRNA TRANSITIVITY RDRs 
Synergistic inhibition of colorectal cancer progression by silencing Aurora A and the targeting protein for Xklp2
《World Journal of Gastrointestinal Surgery》2025年第1期217-233,共17页Gui-Xian Sheng Yu-Jia Zhang Tao Shang 
BACKGROUND Unraveling the pathogenesis of colorectal cancer(CRC)can aid in developing prevention and treatment strategies.Aurora kinase A(AURKA)is a key participant in mitotic control and interacts with its co-activat...
关键词：Aurora kinase A Targeting protein for Xklp2 Microtubule nucleation factor Colorectal cancer Proliferation Migration INVASION 
Silencing the Guns Internal and external challenges to Africa’s security persist,but long-term outlook remains positive
《ChinAfrica》2025年第1期30-32,共3页HE WENPING 
The world in 2024 was far from peaceful.The conflict between Russia and Ukraine has persisted for over 1,000 days.Meanwhile,a new wave of violence in the Palestinian-Israeli conflict,ongoing for more than a year,spill...
关键词：PEACE AFRICA continued 
Core factor of NEXT complex,ZCCHC8,governs the silencing of LINE1 during spermatogenesis
《National Science Review》2025年第1期37-47,共11页Rushuang Yan Meijie Qi Pengfei Zhang Bin Shen Jiqing Yin Chuan Chen Silin Tian Lin Chen Xingxu Huang Hong Wang Shaorong Gao You Wu Yawei Gao 
supported by the National Key R&D Program of China(2020YFA0113200[Y.G.],2021YFC2700300[S.G.]and 2022YFC2702200[S.G.]);the National Natural Science Foundation of China(32370869[Y.G.],32330030[S.G.],92168205[S.G.],32200694[Y.W],82301859[M.Q.]);Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai(S.G.),Young Elite Scientists Sponsorship Program by CAST(2023QNRC001[Y.W]);the key project of the Science and Technology of Shanghai Municipality(21JC1405500[S.G.]);the Shanghai Rising-Star Program(22YF1436200[Y.W.]);the Shanghai Pilot Program for Basic Research(Y.G.),Special Fund for Health Science and Technology of Social Development Shanghai Pudong New Area(PKJ2022-Y20)(L.C.);Fundamental Research Funds for the Central Universities and the China Postdoctoral Science Foundation(2023M733267[P.Z.]).
The overactivation of transposable elements(TEs)is a significant threat to male reproduction,particularly during the delicate process of spermatogenesis.Here,we report that zinc finger protein ZCCHC8-a key component o...
关键词：transposon elements nuclear exosome targeting complex LINE1 spermatogonial stem cells SPERMATOGENESIS 
The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy
《Genes & Diseases》2024年第6期91-94,共4页Wenze Cao Huan Liu Ye Xu Sangyu Hu Yujie Yang Li Li Luying Peng 
supported by grants from the National Natural Science Foundation of China (No.32071109,82070-270,M-0048);the Shanghai Committee of Science and Technology (China) (No.21ZR1467000,22ZR1463800).
RE1 silencing transcription factor(REST)plays a key role in embryonic development and fetal cardiac gene reactivation.1 However,understanding of the role of REST in cardiac remodeling is very limited.A recent study ha...
关键词：cardiac FETAL REST 
Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization
《Research》2024年第4期498-513,共16页Chao Yu Jing Zhao Feng Cheng Jiangjie Chen Jinyang Chen Haibin Xu Kesi Shi Kaishun Xia Siwen Ding Kanbin Wang Ronghao Wang Yazhou Chen Yi Li Hao Li Qixin Chen Xiaohua Yu Fangwei Shao Chengzhen Liang Fangcai Li 
supported by the Distinguished Young Scientist Fund of Zhejiang Province(LR23H060001);National Natural Science Foundation of China(Nos.82272480,82372486,82072481,21975217,and 82072465);“Pioneer”and“Leading Goose”R&D Program of Zhejiang(2024C03243);Dynamic Research Enterprise for Multidisciplinary Engineering Sciences(DREMES)at Zhejiang University and the University of Illinois at Urbana-Champaign,funded by Zhejiang University.
Circular RNAs(circRNAs)play a critical regulatory role in degenerative diseases;however,their functions and therapeutic applications in intervertebral disc degeneration(IVDD)have not been explored.Here,we identified t...
关键词：DEGENERATION thereby adapted 
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