Immune status and combined immunotherapy progression in Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors  

作　　者：Dongsheng He Rilan Bai Naifei Chen Jiuwei Cui 

机构地区：[1]Cancer Center,the First Hospital of Jilin University,Changchun 130021,China

出　　处：《Chinese Journal of Cancer Research》2024年第4期421-441,共21页中国癌症研究（英文版）

基　　金：supported by National Natural Science Foundation of China—Youth Fund Project (No.32000617);Jilin Provincial Science and Technology Department (No.20200602032ZP and No.20210 303002SF);Jilin Provincial Development and Reform Commission (No.2021C10);Changchun Science and Technology Bureau (No.21ZGY28)

摘　　要：Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most frequently mutated oncogene,occurring in various tumor types.Despite extensive efforts over the past 40 years to develop inhibitors targeting KRAS mutations,resistance to these inhibitors has eventually emerged.A more precise understanding of KRAS mutations and the mechanism of resistance development is essential for creating novel inhibitors that target specifically KRAS mutations and can delay or overcome resistance.Immunotherapy has developed rapidly in recent years,and in-depth dissection of the tumor immune microenvironment has led researchers to shift their focus to patients with KRAS mutations,finding that immune factors play an essential role in KRAS-mutant(KRAS-Mut)tumor therapy and targeted drug resistance.Breakthroughs and transitions from targeted therapy to immunotherapy have provided new hope for treating refractory patients.Here,we reviewed KRAS mutation-targeted treatment strategies and resistance issues,focusing on our in-depth exploration of the specific immune status of patients with KRAS mutations and the impact of body immunity following KRAS inhibition.We aimed to guide innovative approaches combining RAS inhibition with immunotherapy,review advances in preclinical and clinical stages,and discuss challenges and future directions.

关 键 词：Cancer KRAS mutation targeted therapy IMMUNOTHERAPY immune microenvironment 

分 类 号：R730.51[医药卫生—肿瘤]