USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells  

作　　者：Kai Li Qian Wang Hua Bian 

机构地区：[1]Zhang Zhongjing College of Chinese Medicine,Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation,Nanyang Institute of Technology,Nanyang,Henan 473004,China [2]College of Orthopaedics and Traumatology,Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China

出　　处：《Genes & Diseases》2024年第5期44-47,共4页基因与疾病（英文）

基　　金：National Nature Science Foundation of China(No.82002592);the Doctoral Research Start-up Fund Project of Nanyang Institute of Technology of China.

摘　　要：Deubiquitinases(DUBs)are a class of enzymes that are able to reverse the process of ubiquitination.1 Extensive research has revealed that there are more than 100 DUBs found in humans,which are classified into seven main families:ubiquitin-specific proteases(USPs),ubiquitin carboxyl-terminal hydrolases,the Machado-Joseph disease domain superfamily,the otubain/ovarian tumor-domain containing proteins,the ZUFSP(Zinc finger with UFM1-specific peptidase domain protein)family,the JAB1/MPN/MOV34 proteases,and the novel motif interacting with ubiquitin-containing DUB family.All DUBs are cysteine proteases,except the JAB1/MPN/MOV34 proteases,which are Zn^(2+) metalloproteases.

关 键 词：ESOPHAGEAL cancer Zinc 

分 类 号：R735.1[医药卫生—肿瘤]