Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases  

作　　者：Arun Upadhyay 

机构地区：[1]Department of Biochemistry,Central University of Rajasthan 305817,India

出　　处：《Acta Pharmaceutica Sinica B》2021年第10期2995-3014,共20页药学学报（英文版）

摘　　要：Cells have different sets of molecules for performing an array of physiological functions.Nucleic acids have stored and carried the information throughout evolution,whereas proteins have been attributed to performing most of the cellular functions.To perform these functions,proteins need to have a unique conformation and a definite lifespan.These attributes are achieved by a highly coordinated protein quality control(PQC)system comprising chaperones to fold the proteins in a proper threedimensional structure,ubiquitin-proteasome system for selective degradation of proteins,and autophagy for bulk clearance of cell debris.Many kinds of stresses and perturbations may lead to the weakening of these protective cellular machinery,leading to the unfolding and aggregation of cellular proteins and the occurrence of numerous pathological conditions.However,modulating the expression and functional efficiency of molecular chaperones,E3 ubiquitin ligases,and autophagic proteins may diminish cellular proteotoxic load and mitigate various pathological effects.Natural medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating these pathways and reestablishing the lost proteostasis inside the cells to combat disease conditions.The present article summarizes various similar reports and highlights the importance of the molecules obtained from natural sources in disease therapeutics.

关 键 词：PROTEOSTASIS Proteinopathies CHAPERONES Ubiquitin proteasome system AUTOPHAGY Cancer NEURODEGENERATION Ageing Natural molecules Drug discovery 

分 类 号：R96[医药卫生—药理学]