Neural functions of small heat shock proteins  

作　　者：Teresa de los Reyes Sergio Casas-Tintó 

机构地区：[1]Instituto Cajal,CSIC,Madrid,Spain

出　　处：《Neural Regeneration Research》2022年第3期512-515,共4页中国神经再生研究（英文版）

摘　　要：Stress response is a cellular widespread mechanism encoded by a common protein program composed by multiple cellular factors that converge in a defense reaction to protect the cell against damage.Among many mechanisms described,heat shock proteins were proposed as universally conserved protective factors in the stress core proteome,coping with different stress stimuli through its canonical role in protein homeostasis.However,emerging evidences reveal non-canonical roles of heat shock proteins relevant for physiological and pathological conditions.Here,we review the implications of inducible heat shock proteins in the central nervous system physiology.In particular,we discuss the relevance of heat shock proteins in the maintenance of synapses,as a balanced protective mechanism in central nervous system development,pathological conditions and aging.

关 键 词：AGING central nervous system CHAPERONES environment NEUROPROTECTION PATHOLOGY stress synapses 

分 类 号：R741.02[医药卫生—神经病学与精神病学]