Zinc alpha 2 glycoprotein(ZAG):A potential novel pharmacological target in diabetic retinopathy  

作　　者：UMAPATHY PRAKASH SUBRAMANIAM RAJESH BHARATHIDEVI RAMYA RNADIG RAJIV R.AMAN GIRISH SHIV RAO MUNA BHENDE 

机构地区：[1]R.S.Mehta Jain Department of Biochemistry and Cell Biology,KNBIRVO,Vision Research Foundation,Sankara Nethralaya,Chennai,600006,India [2]Shri Bhagwan Mahavir Vitreoretinal Services,Sankara Nethralaya,Chennai,600006,India

出　　处：《BIOCELL》2023年第7期1473-1482,共10页生物细胞（英文）

基　　金：the Indian Council of Medical Research(ICMR—(5/4/6/1/OPH/2020-NCD-II)).

摘　　要：Zinc alpha 2 glycoprotein(ZAG)is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum,saliva,sweat,breast milk,and urine.It is also found in tissues like the testis,epididymis,kidney,spleen,liver,lungs,heart,and brain.ZAG is an adipokine with multiple roles,including lipid mobilization,modulating glucose metabolisms,improving insulin sensitivity,inhibiting tumor proliferation through RNAse activity,and suppressing inflammation.Low levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential biomarkers for diabetic nephropathy.Interestingly zinc has been found to regulate the binding of ZAG to fatty acids.Based on very few reports on the vitreous ZAG and based on its known functions,we speculate that ZAG has a potential role in diabetic retinopathy.In this article,we discuss the structural component of the protein,its secretion from various tissues,and its distribution in multiple tissues in normal and disease conditions,especially in diabetes and its complications.

关 键 词：ZAG LIPOLYSIS INFLAMMATION Insulin resistance 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]