KILLER

作品数：349被引量：784H指数：13
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相关机构：中国科学技术大学兰州医学院第二附属医院山东大学中日友好医院更多>>
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Natural killer cell therapy:the key to tackle the bottleneck of cell therapies against solid tumor?
《Science Bulletin》2025年第5期630-633,共4页Dawei Wu Huilei Miao Xiaoxue Ma Matthew Paul McCormack Huiyao Huang Xiaodong Liu Ning Li 
Chinese Academy of Medical Sciences Medical and Health Science and Technology Innovation Project(2023-I2M-C&T-B-094);Beijing Nova Program(20230484277);National key research and development program(2023YFC2508500).
Chimeric Antigen Receptor(CAR)T-cell therapy has shown significant success in hematological cancers,leading to the approval of several products and underscoring the potential of immunotherapy in cancer treatment.Howev...
关键词：KILLER SOLID APPROVAL 
The interplay between natural killer cells and pancreatic stellate cells in pancreatic ductal adenocarcinoma
《Cancer Communications》2025年第2期172-177,共6页Rachel Elizabeth Ann Fincham Parthiban Periasamy Craig Ryan Joseph Jia Meng Jeffrey Chun Tatt Lim Felicia Wee Konstantinos Stasinos Michelle Rodrigues Goulart Jiangfeng Ye Li Yen Chong Bijin Veonice Au Denise Goh Joe Poh Sheng Yeong Hemant Mahendrakumar Kocher 
Pancreatic ductal adenocarcinoma(PDAC)remains one of medicine’s most urgent areas of unmet need.With 5-year survival rates of∼11%,PDAC is set to become the second leading cause of cancer related deaths by 2040[1].Th...
关键词：ADENOCARCINOMA CHEMOTHERAPY KILLER 
Comprehensive snapshots of natural killer cells functions,signaling,molecular mechanisms and clinical utilization
《Signal Transduction and Targeted Therapy》2024年第12期5431-5469,共39页Sumei Chen Haitao Zhu Youssef Jounaidi 
Supported by Innovation Grants DAPCM(232129,245130);President and Fellows of Harvard College Myles shore fellowship(241317)to Y.J.S.C;supported by Scientific Research Funds of Zhejiang Province Health Department 2024ky205;Hangzhou Agricultural and Social Development Key Scientific Research Project 202004A19;supported by Guizhou Province Science Technology Project(2024)051.
Natural killer(NK)cells,initially identified for their rapid virus-infected and leukemia cell killing and tumor destruction,are pivotal in immunity.They exhibit multifaceted roles in cancer,viral infections,autoimmuni...
关键词：KILLER HEALING WOUND 
Holistic Healing
《ChinAfrica》2024年第11期44-45,共2页DERRICK SILIMINA 
When Tom Dambudzo was bedridden due to ill health in his rural village,taking painkillers was the only option for him to relieve pain.“I couldn’t walk properly when I had severe backache for six months and my depend...
关键词：DRUGS PAIN KILLER 
Myocarditis–A silent killer in athletes:Comparative analysis on the evidence before and after COVID-19 pandemic
《Sports Medicine and Health Science》2024年第3期232-239,共8页Jonathan Van Name Kainuo Wu Lei Xi 
Myocarditis is a rare cardiomyocyte inflammatory process,typically caused by viruses,with potentially devastating cardiac sequalae in both competitive athletes and in the general population.Investigation into myocardit...
关键词：COVID-19 MYOCARDITIS Cardiovascular symptomatology Athlete susceptibility Return-to-play Sudden cardiac death Viral pathogens High-intensity exercise 
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
《Current Medical Science》2024年第3期545-553,共9页Shi-gui PANG Xin ZHANG Zhao-xin LI Li-fei HE Feng CHEN Ming-long LIU Ying-ze HUANG Jian-mei MO Kong-lan LUO Juan-juan XIAO Feng ZHU 
supported by the Guangxi Zhuang Autonomous Region Program of China(No.Z-C20220797);Guangxi Science and Technology Planning Project of China(No.Guike AD20297047);National Natural Science Foundation of China(No.81902849).
Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistanc...
关键词：T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response RADIOSENSITIVITY 
Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study被引量：3
《Signal Transduction and Targeted Therapy》2024年第6期2765-2773,共9页Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru Feng Wenyu Li Yin Xiao Xinxiu Liu Yu Chen Xiaoxiao Wang Bing Bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao Huiqiang Huang 
supported by the National Natural Science Foundation of China(grant numbers 82170188 and 81970176);Guangdong Basic and Applied Basic Research Foundation(grant number 2021A1515110012).
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be improved....
关键词：KILLER LYMPHOMA doses 
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma被引量：2
《Signal Transduction and Targeted Therapy》2024年第4期1665-1674,共10页Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao 
supported,in part,by research funding from the National Natural Science Foundation of China (82130004 and 82270194);National key research and development program (2022YFC2502600);Chang Jiang Scholars Program,Shanghai Rising-Star Program (23QA1406100);Shanghai Municipal Commission of Science and Technology Project (23141903100);Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support (20152206,20152208,and 20161303);Clinical Research Plan of Shanghai Hospital Development Center (SHDC 2020CR1032B);Multicenter Clinical Research Project by Shanghai Jiao Tong University School of Medicine (DLY201601)。
Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive chemotherapy.To explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we co...
关键词：KILLER METABOLISM LYMPHOMA 
Relationship between killer cell immunoglobulin-like receptor genes and immune reconstitution failure in human immunodeficiency virus infection/acquired immunodeficiency syndrome patients after anti-retroviral therapy
《China Medical Abstracts(Internal Medicine)》2024年第1期25-25,共1页梅馨尹 
Objective To analyze the relationship between killer cell immunoglobulin-like receptor (KIR) genes and immune reconstitution failure in human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AI...
关键词：KILLER IMMUNODEFICIENCY PATIENTS 
A retrospective analysis of mature T-and NK-cell lymphomas被引量：2
《Cancer Biology & Medicine》2024年第3期223-229,共7页Junlei Jia Xiaohui Wang Zheng Song Shen Meng Yue Fei Jingwei Yu Xia Liu Xue Han Lanfang Li Lihua Qiu Zhengzi Qian Shiyong Zhou Wenchen Gong Bin Meng Xiubao Ren Xianhuo Wang Huilai Zhang 
supported by the Construction Project of Cancer Precision Diagnosis and Drug Treatment Technology(Grant No. ZLJZZDYYWZL04);the Clinical Oncology Research Fund of CSCO(Grant No. Y-SY2021MS-0240);the Haihe Yingcai(Tianjin)Project(Grant No. TJSJMYXYC-D2-039);the Tianjin Key Medical Discipline(Specialty)Construction Project grant(Grant No. TJYXZDXK-009A);the CACA-BeiGene Lymphoma Research Foundation(Grant No.CORP-117)。
Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according...
关键词：LYMPHOMA NEOPLASMS KILLER 
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