REFRACTORY

作品数：657被引量：1420H指数：15
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相关领域：医药卫生更多>>
相关作者：徐秋霞汪方跃李元李茵赵代鑫更多>>
相关机构：第三军医大学西南医院中山大学中国科学院上海市第一人民医院更多>>
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Refractory Crohn's disease complicated with Guillain-Barré syndrome:A case report
《World Journal of Clinical Cases》2025年第18期94-100,共7页A-Niu Liu Jia-Yi Yang Xing-Yu Chen Shan-Shan Wu Se-Niu Ji Zhi Shu-Mei Zheng 
BACKGROUND Inflammatory bowel disease(IBD)comprises a group of chronic inflammatory gastrointestinal disorders,including Crohn's disease(CD)and ulcerative colitis,with uncertain etiologies.The natural course of IBD ca...
关键词：Inflammatory bowel disease Crohn's disease Ulcerative colitis Guillain-Barrésyndrome Biological agents Case report 
Integrating multi-omics methods for personalized treatment of refractory chronic myelomonocytic leukemia with NRAS and TET2 mutations
《Cancer Pathogenesis and Therapy》2025年第2期173-175,共3页Chuandong Hou Bo Yang Yue Wang Lili Cai Ran Qin Bo Guo Jie Geng XueChun Lu 
supported by the Multi-Center Clinical Research Project of the National Clinical Research Center for Geriatric Diseases(No.NCRCG-PLAGH-20230010);the Key Military Health Project(No.23BJZ25).
Chronic myelomonocytic leukemia(CMML),a rare and malignant hematologic disorder,is classified as a myelodysplastic/myeloproliferative neoplasm(MDS/MPN).1 It poses a significant risk of progression to acute myeloid leu...
关键词：chronic myelomonocytic leukemia cmml personalized treatment demethylation therapy acute myeloid leukemia refractory chronic myelomonocytic leukemia multi omics Nras mutations Tet mutations 
Therapeutic effectiveness of intratympanic and retroauricular methylprednisolone sodium succinate for refractory sudden sensorineural hearing loss in diabetic patients
《World Journal of Diabetes》2025年第5期159-168,共10页Dong Li Fei Qiao Jun Dai Min Xu He-Yan Gong Hui-Ming Yang Jing-Cheng Li De Huai 
Supported by 2023 Science and Technology Innovation Program(Key Laboratory of Sleep Respiratory Disorders)in Huai'an,No.HAP202304。
BACKGROUND Managing refractory sudden sensorineural hearing loss(RSSHL)in patients with diabetes mellitus(DM)presents significant therapeutic challenges,highlighting the importance of identifying effective treatment s...
关键词：Intratympanic injection Retroauricular injection Refractory sudden hearing loss Diabetes mellitus Therapeutic effectiveness 
Machine-Learning-Assisted Compositional Design of Refractory High-Entropy Alloys with Optimal Strength and Ductility
《Engineering》2025年第3期214-223,共10页Cheng Wen Yan Zhang Changxin Wang Haiyou Huang Yuan Wu Turab Lookman Yanjing Su 
financial support of the National Key Research and Development Program of China(2021YFB3802100);the National Natural Science Foundation of China(52203293);the Innovation Centre of Nuclear Materials Fund(ICNM-2022-ZH-02).
Designing refractory high-entropy alloys(RHEAs)for high-temperature(HT)applications is an outstanding challenge given the vast possible composition space,which contains billions of candidates,and the need to optimize ...
关键词：Machine learning Refractory high-entropy alloys Multi-objective optimization Strength-ductility design 
Treatment of refractory thoracolumbar spine infection by thirteen times of vacuum sealing drainage:A case report
《World Journal of Orthopedics》2025年第3期105-114,共10页Jun-Jie Wu Zheng-Qi Chang 
Supported by Natural Science Foundation of Shandong Province,No.ZR2023MH331.
BACKGROUND A case study of multiple distinct levels of skipped thoracolumbar spine infection was reported in which 13 successful vacuum sealing drainage(VSD)surgeries were treated.CASE SUMMARY The patient underwent a ...
关键词：Infectious diseases of the spine Intervertebral space infection Refractory thoracolumbar spine infection Vacuum sealing drainage Extreme lateral interbody fusion Case report 
A Novel BCC/B2 Structural Nb_(38)Ti_(35)Al_(15)V_(6)Cr_(4)(TaHfMoW)_(2) Refractory High‑Entropy Alloy with Excellent Specifc Yield Strength‑Plasticity Synergy
《Acta Metallurgica Sinica(English Letters)》2025年第3期396-406,共11页Hongbin Liu Zhenqiang Xing Yitong Yang Jingyu Pang Wen Li Zhengwang Zhu Long Zhang Aimin Wang Haifeng Zhang Hongwei Zhang 
supported by the Chinese Academy of Sciences(ZDBS-LY-JSC023),the National Natural Science Foundation of China(No.52404370);the Natural Science Foundation of Liaoning Province(2023-BS-012);the Youth Innovation Promotion Association CAS(2021188);the IMR Innovation Fund(2023-PY16);the Guangdong Basic and Applied Basic Research Foundation(2023A1515111060).
Refractory high-entropy alloys(RHEAs)stand as promising candidates for the development of a new generation of hightemperature materials due to their exceptional mechanical properties.However,the inherent low ductility...
关键词：Refractory high entropy alloy B2 phase Microstructure Mechanical property Deformation mechanism 
Granulocyte colony-stimulating factor in neutropenia management after CAR-T cell therapy:A safety and efficacy evaluation in refractory/relapsed B-cell acute lymphoblastic leukemia
《Chinese Medical Journal》2025年第1期111-113,共3页Xinping Cao Meng Zhang Ruiting Guo Xiaomei Zhang Rui Sun Xia Xiao Xue Bai Cuicui Lyu Yedi Pu Juanxia Meng Huan Zhang Haibo Zhu Pengjiang Liu Zhao Wang Yu Zhang Wenyi Lu Hairong Lyu Mingfeng Zhao 
supported by grants from the General Project of the National Natural Science Foundation of China(No.81970180);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022QN030);the Key projects of Tianjin Applied Basic Research and Multi-Investment Fund(No.21JCZDJC01240);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022XK018);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-056B);Tianjin Municipal Natural Science Foundation(No.22JCQNJC00820);Tianjin Health Research Project(No.TJWJ2023QN027);Tianjin Health Bureau Project(No.ZC20074);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJWJ2023XK010);Henan Provincial Youth and Middle-aged Health Science and Technology Talents Excellent Youth Program(No.20230273).
To the Editor:After chimeric antigen receptor T(CAR-T)cell therapy,over 90%of patients experience either mild or severe cytopenia,with the prevalence of Grades 3–4 neutropenia ranging from 53%to 94.3%.[1,2]Granulocyt...
关键词：anti inflammatory effects efficacy cytokine release syndrome chimeric antigen receptor T cell therapy NEUTROPENIA granulocyte colony stimulating factor 
Effect of h-BN rods on high-temperature properties of alumina-carbon refractory
《Journal of Iron and Steel Research International》2025年第1期115-128,共14页Ya-ge Li Shuai-bing Wu Feng Liang Zhong Huang Tu Long Long Dong Jun-yi Lv Hong-juan Duan Biao Wen Yong Liu Hai-jun Zhang 
support from the National Natural Science Foundation of China(Grant Nos.52072274,52272021,U23A20559 and 52232002);the Open Foundation of State Key Laboratory of Advanced Refractories(No.SKLAR202207);the Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials(Wuhan University of Science and Technology,WKDM202201);the Open/Innovation Foundation of Hubei Three Gorges Laboratory(SK232006).
h-BN rods modified low-carbon alumina-carbon(Al_(2)O_(3)-C)refractories were prepared,and the effect of h-BN rod addition on the high-temperature properties was investigated and compared with commercial h-BN flake,car...
关键词：Al_(2)O_(3)-C refractory h-BN rod MICROSTRUCTURE High-temperature service performance 
High strength-ductility synergy in refractory multi-principal element alloys via special deformation mechanisms and dislocation behaviors
《Rare Metals》2025年第1期608-622,共15页Zhi-Wen Li Bao-Xian Su Liang Wang Chen Liu Zhe Li Qing-Da Zhang Bin-Bin Wang Xiang Xue Rui-Run Chen Yan-Qing Su 
supported by the National Key Research and Development Program of China(No.2022YFF0609000);the National Natural Science Foundation of China(Nos.52171034 and 52101037);the Postdoctoral Fellowship Program of CPSF(No.GZB20230944).
Ti-Zr-Nb refractory multi-principal element alloys(RMPEAs)have attracted increased attention due to their excellent mechanical properties.In this study,(TiZr)_(80-x)Nb_(20)Mo_(x)(x=0,5 and 10)alloys were designed,and ...
关键词：Refractory multi-principal element alloy Mechanical property Strengthening mechanism Deformation substructure Dislocation behavior 
An assessment model for efficacy of autologous CD19 chimeric antigen receptor T-cell therapy and relapse or refractory diffuse large B-cell lymphoma risk
《Chinese Medical Journal》2025年第1期108-110,共3页Bin Xue Yifan Liu Min Zhang Gangfeng Xiao Xiu Luo Lili Zhou Shiguang Ye Yan Lu Wenbin Qian Li Wang Ping Li Aibin Liang 
supported by grants from the National Key R&D Program of China(No.2021YFA1100800);National Natural Science Foundation of China(Nos.81830004 and 82070168);Translational Research Grant of NCRCH(No.2020ZKZC04);Shanghai Municipal Health Commission(No.2020CXJQ02);Cultivation project of National Natural Science Foundation of Shanghai Tongji Hospital(No.GJPY2332).
To the Editor:Autologous CD19 chimeric antigen receptor(CAR)T-cell therapy has emerged as a crucial treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma(r/r DLBCL).[1]While CAR-T-cel...
关键词：therapeutic efficacy chimeric antigen REFRACTORY predictive model Chimeric Antigen Receptor T cell therapy diffuse large B cell lymphoma 
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