Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current s...
supported by Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)#1200836,#1210644,and#1240888,and Agencia Nacional de Investigación y Desarrollo(ANID)-FONDAP#15130011(to LL);FONDECYT#3230227(to MFG).
Astrocytes are the most abundant type of glial cell in the central nervous system.Upon injury and inflammation,astrocytes become reactive and undergo morphological and functional changes.Depending on their phenotypic ...
The increasing incidence of neurodegenerative diseases(NDs)and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies.Medicinal plants,renowned for their long...
supported by the National Natural Science Foundation of China (No.81973568);the Earmarked Fund for China Agriculture Research System (No.CARS-21);the Special Financial Project of the Ministry of Agriculture and Rural Areas (No.NFZX2024)。
Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 26carbons,ganothenoids A-E(1-5),and three lanostanoids,ganothenoids F-H(6-8),along with 24 known ones(9-32),were isolated from ...
supported by the funding listed as follows:National Key R&D Program of China(Nos.2018YFC2002100 and 2018YFC2002103);Science and Technology Department of Sichuan Province(Grant No.24ZYZYTS0172 and 2025ZNSFSC1021,China);the Key R&D Support Program of Chengdu(No.2022YF0900001SN,China),National Natural Science Foundation of China(No.32301115);National Key Research and Development Programs(2023YFC2412802,China);Fundamental Research Funds for the Central Universities(2023SCUH0011 and YJ2021115,China).
Stroke is a global disease that seriously threatens human life.The pathological mechanisms of ischemic stroke include neuroinflammation,oxidative stress,and the destruction of blood vessels at the lesion site.Here,a b...
supported by Karolinska Institutet in the form of a Board of Research Faculty Funded Career Position;by St.Erik Eye Hospital philanthropic donations;Vetenskapsrådet 2022-00799.
Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues.Pyrroloquinoline quinone is present in the di...
funded by the Research Deanship of King Khalid University,No.GRP-215-43 (to FHA);Princess Nourah bint Abdulrohman University Researchers Supporting Project,No.PNURSP2023R110 (to AFD)。
Memory loss and dementia are major public health concerns with a substantial economic burden.Oxidative stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory impairmen...
supported by Russian science foundation(grant 21-75-30009).
Background: The active use of stem and progenitor cells in the therapy of various diseases requires thedevelopment of approaches for targeted modification of their properties. One such approach is the induction of a p...
supported by the Major Program of the National Natural Science Foundation of China(62394310,62394313,62394314);the National Natural Science Foundation of China(12126601);the R&D project of Pazhou Lab(Huangpu)(2023K0608);the China Postdoctoral Science Foundation(2022M720294);Intelligent Basic Theory Innovation Research fund(201CXCY-A01-08-00-29);GuangDong Basic and Applied Basic Research Foundation(2022A1515110674);Medical Scientific Research Foundation of Guangdong Province of China(B2022067);Science Foundation of AMHT(2021YK11)。
Ischemic stroke is a leading cause of death and disability worldwide.Inflammatory response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial impla...