NEUROPROTECTIVE

作品数:163被引量:337H指数:9
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相关作者:程介士孙安阳吴蔚然卢宏蒋超更多>>
相关机构:上海医科大学郑州大学第二附属医院郑州大学第一附属医院中国科学院上海生命科学研究院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage
《Neural Regeneration Research》2025年第8期2199-2217,共19页Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang 
Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current s...
关键词:apoptosis autophagy blood-brain barrier dietary supplements drug HORMONES inflammation NEUROPROTECTION oxidative stress prognosis PYROPTOSIS reperfusion injury risk factors RNA THERAPEUTICS 
Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions
《Neural Regeneration Research》2025年第4期1031-1041,共11页Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton 
supported by Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)#1200836,#1210644,and#1240888,and Agencia Nacional de Investigación y Desarrollo(ANID)-FONDAP#15130011(to LL);FONDECYT#3230227(to MFG).
Astrocytes are the most abundant type of glial cell in the central nervous system.Upon injury and inflammation,astrocytes become reactive and undergo morphological and functional changes.Depending on their phenotypic ...
关键词:inflammation INTEGRINS NEUROPROTECTIVE NEUROTOXIC phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90) 
Correction to:Scorpion Venom Heat‑Resistant Peptide is Neuroprotective Against Cerebral Ischemia‑Reperfusion Injury in Association with the NMDA‑MAPK Pathway
《Neuroscience Bulletin》2025年第3期549-550,共2页
Exploring the neuroprotective benefits of phytochemicals extracted from indigenous edible fruits in Bangladesh
《Animal Models and Experimental Medicine》2025年第2期239-265,共27页Sumon Roy Sajib Chandra Roy Mehrukh Zehravi Sherouk Hussein Sweilam Rajib Das Mylsamy Palanisamy Venkata Lakshamana Sagar Dantinapalli Selvaraja Elumalai Jeetendra Kumar Gupta Mohammed Ali Alshehri Mohammed Asiri Irfan Ahmad Mohamed HNafady Talha Bin Emran 
The increasing incidence of neurodegenerative diseases(NDs)and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies.Medicinal plants,renowned for their long...
关键词:BANGLADESH edible fruit plants NEUROPROTECTION PHYTOCHEMICALS traditional medicine 
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum
《Chinese Journal of Natural Medicines》2025年第2期245-256,共12页Jiaocen Guo Li Yang Luting Dai Qingyun Ma Jiaoyang Yan Qingyi Xie Yougen Wu Haofu Dai Youxing Zhao 
supported by the National Natural Science Foundation of China (No.81973568);the Earmarked Fund for China Agriculture Research System (No.CARS-21);the Special Financial Project of the Ministry of Agriculture and Rural Areas (No.NFZX2024)。
Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 26carbons,ganothenoids A-E(1-5),and three lanostanoids,ganothenoids F-H(6-8),along with 24 known ones(9-32),were isolated from ...
关键词:Ganoderma theaecolum Lanostane nortriterpenoids Neuroprotective effects PTP1B Α-GLUCOSIDASE 
NO-releasing double-crosslinked responsive hydrogels accelerate the treatment and repair of ischemic stroke
《Acta Pharmaceutica Sinica B》2025年第2期1112-1125,共14页Wen Guo Cheng Hu Yue Wang Wen Zhang Shaomin Zhang Jin Peng Yunbing Wang Jinhui Wu 
supported by the funding listed as follows:National Key R&D Program of China(Nos.2018YFC2002100 and 2018YFC2002103);Science and Technology Department of Sichuan Province(Grant No.24ZYZYTS0172 and 2025ZNSFSC1021,China);the Key R&D Support Program of Chengdu(No.2022YF0900001SN,China),National Natural Science Foundation of China(No.32301115);National Key Research and Development Programs(2023YFC2412802,China);Fundamental Research Funds for the Central Universities(2023SCUH0011 and YJ2021115,China).
Stroke is a global disease that seriously threatens human life.The pathological mechanisms of ischemic stroke include neuroinflammation,oxidative stress,and the destruction of blood vessels at the lesion site.Here,a b...
关键词:Hydrogel Nitric oxide Ischemic stroke Angiogenesis Anti-inflammation Macrophage migration inhibitory factor NEUROPROTECTIVE Double-crosslinked 
Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism
《Neural Regeneration Research》2025年第1期41-53,共13页Alessio Canovai Pete A.Williams 
supported by Karolinska Institutet in the form of a Board of Research Faculty Funded Career Position;by St.Erik Eye Hospital philanthropic donations;Vetenskapsrådet 2022-00799.
Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues.Pyrroloquinoline quinone is present in the di...
关键词:METABOLISM MITOCHONDRIA neurodegenerative disease NEUROPROTECTION pyrroloquinoline quinone retinal diseases 
Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression
《Neural Regeneration Research》2024年第12期2750-2759,共10页Fahaid H.A.L-Hashem Salah O.Bashir Amal F.Dawood Moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni Mohamed D.Morsy 
funded by the Research Deanship of King Khalid University,No.GRP-215-43 (to FHA);Princess Nourah bint Abdulrohman University Researchers Supporting Project,No.PNURSP2023R110 (to AFD)。
Memory loss and dementia are major public health concerns with a substantial economic burden.Oxidative stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory impairmen...
关键词:HIPPOCAMPUS NEUROPROTECTIVE Nrf2 gene oxidative stress vanillylacetone 
Changes in bioenergetics and neuroprotective properties of mesenchymal stromal cells after LPS treatment
《BIOCELL》2024年第12期1827-1834,共8页ELMIRA YAKUPOVA VALENTINA BABENKO ALEXEY BOCHARNIKOV KSENIYA FEDULOVA DENIS SILACHEV EGOR PLOTNIKOV 
supported by Russian science foundation(grant 21-75-30009).
Background: The active use of stem and progenitor cells in the therapy of various diseases requires thedevelopment of approaches for targeted modification of their properties. One such approach is the induction of a p...
关键词:Cell therapy LIPOPOLYSACCHARIDE STROKE NEUROPROTECTION BIOENERGETICS Inflammation GLYCOLYSIS 
A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid
《Science China(Life Sciences)》2024年第10期2213-2223,共11页Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor Serrano Lopes Fangxiao Cheng Junhao Yan Yu Fu Wanyi Fu Zhaoheng Xie Jianfei Sun Jicong Zhang Zhiqian Tong Yajuan Gao Hongbin Han 
supported by the Major Program of the National Natural Science Foundation of China(62394310,62394313,62394314);the National Natural Science Foundation of China(12126601);the R&D project of Pazhou Lab(Huangpu)(2023K0608);the China Postdoctoral Science Foundation(2022M720294);Intelligent Basic Theory Innovation Research fund(201CXCY-A01-08-00-29);GuangDong Basic and Applied Basic Research Foundation(2022A1515110674);Medical Scientific Research Foundation of Guangdong Province of China(B2022067);Science Foundation of AMHT(2021YK11)。
Ischemic stroke is a leading cause of death and disability worldwide.Inflammatory response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial impla...
关键词:ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation 
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