Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism  

作　　者：Alessio Canovai Pete A.Williams 

机构地区：[1]Department of Biology,University of Pisa,Pisa,Italy [2]Department of Clinical Neuroscience,Division of Eye and Vision,St.Erik Eye Hospital,Karolinska Institutet,Stockholm,Sweden

出　　处：《Neural Regeneration Research》2025年第1期41-53,共13页中国神经再生研究（英文版）

基　　金：supported by Karolinska Institutet in the form of a Board of Research Faculty Funded Career Position;by St.Erik Eye Hospital philanthropic donations;Vetenskapsrådet 2022-00799.

摘　　要：Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues.Pyrroloquinoline quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary administration.Pyrroloquinoline quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many studies.In this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian life.Through the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and death.Pyrroloquinoline quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully elucidated.Here,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological contexts.In addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关 键 词：METABOLISM MITOCHONDRIA neurodegenerative disease NEUROPROTECTION pyrroloquinoline quinone retinal diseases 

分 类 号：R741[医药卫生—神经病学与精神病学]