CYTOTOXIC

作品数：334被引量：727H指数：11
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相关机构：北京大学中国海洋大学吉林大学第一医院中国医科大学更多>>
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Chemical Composition, Antioxidant and Anticancer Activities of Thymus capitatus Essential Oil:Experimental and Computational Approaches
《Phyton-International Journal of Experimental Botany》2025年第3期723-737,共15页Hamada Imtara Feras Abujaber Faady Siouri Aziz Tumeh Bashar Saad 
Traditional Palestinian medicine uses Thymus capitatus (T. capitatus), a plant recognized for its therapeutic properties due to its high concentration of essential oils such as thymol and carvacrol, to treat skin dise...
关键词：Thymus capitatus gas chromatography-mass spectrometry(GC-MS) DOCKING CYTOSTATIC CYTOTOXIC 
A recombinant fragment antigen-binding(Fab)of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes:first evidence and the key implication of FcγRIIA receptor
《Acta Pharmacologica Sinica》2025年第3期618-631,共14页Anna De Bartolo Naomi Romeo Alessandro Marrone Vittoria Rago Maria Concetta Granieri Maria Luigia Vommaro Arianna Cupelli Maria Carmela Cerra Cesare Indiveri Raffaele Ronca Maria Cantile Riccardo Sanna Carmine Rocca Tommaso Angelone 
supported by“SI.F.I.PA.CRO.DE.–Sviluppo e industrializzazione farmaci innovativi per terapia molecolare personalizzata PA.CRO.DE”(PON ARS01_00568).
Fragment crystallizable gamma receptors(FcγRs)mediate various cellular responses with significant cardiovascular implications.They contribute to the anticancer activity of trastuzumab(TRZ),a recombinant humanized mon...
关键词：cardiac complications TRASTUZUMAB rFab-HER2 Fc region FcyRIIA HER2 
Analyzing the Cytotoxic and Genetic Impact of Datura stramonium Extract on MCF7 and HT29 Cancer Cells:A Metabolite and Gene Expression Study
《Phyton-International Journal of Experimental Botany》2025年第1期181-198,共18页Fayez Althobaiti Hadeer Darwish Raghad Alruqayb Saqer S.Alotaibi Fahad E.Alharthi Ibrahim Jafri Sarah Awwadh Altalhi Ghadi Alsharif Hussam Awwadh E Althagafi Hesham Noureldeen Sarah Alharthi Jawaher Albaqami Najla Amin T.Al Kashgry Ahmed Noureldeen 
Taif University,Saudi Arabia,Project No.(TU-DSPP-2024-74).
The interest in using the Datura stramonium plant is due to its natural products,which are used in many pharmaceutical industries.The objective of the current study was to assess the therapeutic and cytotoxic effects ...
关键词：Datura stramonium secondary metabolites GC-MS analysis CYTOTOXICITY breast and colon cancer cell lines MTT assay 
A human-specific cytotoxic neopeptide generated by the deafness gene Cingulin
《Journal of Genetics and Genomics》2024年第11期1215-1227,共13页Yuhang Huang Linqing Zhang Yuecen Sun Qing Liu Jie Chen Xiaoyun Qian Xia Gao Guang-Jie Zhu Guoqiang Wan 
supported by the National Natural Science Foundation of China(82171136 and 92368110 to G.W.,82201291 to G.-J.Z.,82171145 to X.Q.,81870721 to J.C.,and 81970884 and 82192862 to X.G.);Natural Science Foundation of Jiangsu Province(BK20220189to G.-J.Z.and BK20220188 to Q.L.);Special Foundation for Health Science and Technology Development of Nanjing(YKK21109 to G.-J.Z.);the Clinical Research Foundation of Drum Tower Hospital affiliated to Nanjing University Medical School(2021-LCYJ-PY-04 to G.-J.Z.)。
Accumulation of mutant proteins in cells can induce proteinopathies and cause functional damage to organs.Recently,the Cingulin(CGN)protein has been shown to maintain the morphology of cuticular plates of inner ear ha...
关键词：Proteinopathy AGGREGATE Neopeptide Cell death CINGULIN Hearing loss 
Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus
《Chinese Journal of Natural Medicines》2024年第9期822-830,共9页WU Jun SONG Tao ZHANG Le HUANG Zhongdi HUANG Fang YIN Caiping ZHANG Shuxiang LIU Xinhua ZHANG Yinglao 
supported by the Natural Science Funds for Distinguished Young Scholars of Anhui Province(No. 2108085J18);the National Natural Science Foundation of China (Nos. 32011540382 and 32102272)。
Chemical investigations of the termite-associated Streptomyces tanashiensis BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B(1 and 2), exfoliazone A(3), and venezueline H(7), i...
关键词：Odontotermes formosanus Streptomyces tanashiensis ALKALOID Cytotoxic activity Antibacterial activity Biosynthetic pathway 
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis,a China's endemic plant species
《Chinese Journal of Natural Medicines》2024年第9期831-841,共11页SUN Yanjun ZHAO Chen BAI Hongyun LI Meng WANG Junmin HAO Zhiyou FENG Weisheng 
supported by the Key Research Project of Higher Education Institution in Henan Province (No.24A360015);the Scientific and Technological Key Project in Henan Province (No. 192102310438);the Program for Innovative Research Team (in Science and Technology) in University of Henan Province(No. 24IRTSTHN039);the Research Project on Chinese Medicine Science in Henan Province (No. 20-21ZY1039)。
Eight novel arylnaphthalide lactone lignans, designated as diphylignan A-H(1-8), and a new dibenzyltyrolactone lignan, designated as diphylignan I(9), were isolated from the roots and rhizomes of Diphylleia sinensis, ...
关键词：Diphylleia sinensis Dibenzyltyrolactone Arylnaphthalide CYTOTOXIC 
Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach
《Emerging Contaminants》2024年第2期76-82,共7页Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun Kim 
Chromium(III)oxide nanoparticles(NPs)have a wide range of industrial applications,particularly in the production of lithium-ion batteries;however,the toxicity of these NPs has not been studied extensively.The phytotox...
关键词：NANOPARTICLE Plant growth Cell viability Chromium(III)oxide NEPHROTOXICITY 
Cytotoxic Properties on Cervical and Liver Cancer Cells of Two Plant Recipes from Burkina Faso
《Journal of Biosciences and Medicines》2024年第6期216-229,共14页Estelle Ouédraogo Bagora Bayala Théodora Mahoukèdè Zohoncon Samiratou Ouédraogo Olga Mélanie Lompo Essi Etonam Dovo Jean-Marie Compaoré Albert Théophane Yonli Jacques Simpore 
Cancer is one of the deadliest diseases in developing countries. In recent years, natural plant-based compounds have been used in the search for drugs to combat numerous diseases, including cancer. In this study, we e...
关键词：ANTIOXIDANT ANTI-INFLAMMATORY CYTOTOXICITY Paanfo Tiben Burkina 
Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells
《The Innovation》2024年第3期138-145,共8页Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan Ang Guo Sijo Mathew Dali Sun 
The authors acknowledge North Dakota State University Center for Computationally Assisted Science and Technology for computing resources.This work was financially supported by grants from the National Cancer Institute(R21CA270748,R03CA252783)and the National Institute of General Medical Sciences(U54GM128729)of National Institutes of Health to D.S.,NDSU EPSCoR STEM Research and Education fund(FAR0032086)to D.S.,ND EPSCoR:Advancing Science Excellence in ND(FAR0030554)to D.S.,and National Science Foundation(NSF)under NSF EPSCoR Track-1 Cooperative Agreement(OIA no.1355466)to D.S.,the National Institue of General Medical Sciences(P20GM109036)to J.F.,NSF under NSF OIA ND-ACES(award no.1946202)to W.X.,and NDSU Foundation and Alumni Association to D.S.
Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease stages.Innovative and selective...
关键词：finding identif SELECTIVITY 
Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells被引量：1
《Bioactive Materials》2024年第6期301-316,共16页Sonia Kiran Yu Xue Drishty B.Sarker Yan Li Qing-Xiang Amy Sang 
supported by the National Science Foundation(CBET-1652992 and CBET-1917618 to Y.L.).
Natural killer(NK)cells are cytotoxic immune cells that can eliminate target cells without prior stimulation.Human induced pluripotent stem cells(iPSCs)provide a robust source of NK cells for safe and effective cell-b...
关键词：Human induced pluripotent stem cells Natural killer cells Atypical teratoid rhabdoid tumor Cytotoxicity Cytokine activation 
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