Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach  

作　　者：Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun Kim 

机构地区：[1]Department of Biology,Jeju National University,Jeju,63243,South Korea [2]Department of Interdisciplinary Program in Biomedical Science,Graduate School,Soonchunhyang University,Asan,Chungcheongnam-do,South Korea [3]Department of Laboratory Medicine,Soonchunhyang University Seoul Hospital,Seoul,04401,South Korea

出　　处：《Emerging Contaminants》2024年第2期76-82,共7页新兴污染物（英文）

摘　　要：Chromium(III)oxide nanoparticles(NPs)have a wide range of industrial applications,particularly in the production of lithium-ion batteries;however,the toxicity of these NPs has not been studied extensively.The phytotoxicity and genotoxicity of chromium(III)oxide NPs have not been assessed,and only one study reported their cytotoxicity,underscoring the need to perform comprehensive toxicity studies on these NPs.Here,we showed that chromium(III)oxide NPs had no effect on germination rates,and only decreased root elongation in L.sativa as determined by root elongation and biomass studies.Chromium(III)oxide NPs had no phytotoxic effects under environmental realistic conditions,whereas they had cytotoxic effects against HK-2 and Raw 264.7 cells in vitro.However,the cytotoxicity of chromium(III)oxide NPs did not occur under environmentally realistic conditions.The genotoxicity of chromium(III)oxide NPs was not significant in HK-2 cells,suggesting that the potential environmental cytotoxicity of chromium(III)oxide NPs is limited.This study proposes comprehensive phytotoxicity,cytotoxicity,and genotoxicity testing tools that would be easy,safe,and effective for evaluating the toxicity of NPs.This integrated testing system could be an accurate and stable method for evaluating the toxicity of other nanomaterials.

关 键 词：NANOPARTICLE Plant growth Cell viability Chromium(III)oxide NEPHROTOXICITY 

分 类 号：TB383[一般工业技术—材料科学与工程]