A multifunctional baicalin-coordinated borate ions/bacterial cellulose composite hydrogel for efficient treatment of chronic wounds  

作　　者：Wenxin Zhang Shubi Zhao Siwen Wu Tianran Song Qifeng Guan Junwei Xu Jingxi Wang Ping Li Yubo Fan 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China [2]Department of Critical Medicine,School of Medicine,Shenzhen People's Hospital,First Affiliated Hospital of Southern University of Science and Technology,Second Clinical Medical College of Jinan University,Shenzhen,Guangdong,China [3]Department of Blood Transfusion,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310003,China [4]School of Medical Science and Engineering,Beihang University,Beijing,100083,China

出　　处：《Medicine in Novel Technology and Devices》2024年第3期70-80,共11页医学中新技术与新装备（英文）

基　　金：supported by funds from National Natural Science Foundation of China(NSFC)Research Grants(52072015,62273019,U20A20390,11827803);the 111 Project(B13003).

摘　　要：Microbial infection,poor vascular regeneration and abnormal inflammation often impede the smooth repair of skin wounds,and these problems need to be effectively addressed.Baicalin is a natural flavonoid compound with a wide range of beneficial pharmacological effects,including antibacterial,angiogenic and anti-inflammatory properties.However,its clinical application is severely limited by poor water solubility and low bioavailability.In this study,we developed a multifunctional baicalin-coordinated borate ions/bacterial cellulose(Bai-B/BC)composite hydrogel at a low gelation concentration to promote chronic wound healing.On the one hand,the mechanical property of the self-assembled Bai-B hydrogel network was improved by the BC hydrogel network in the composite hydrogel;on the other hand,the self-assembled Bai-B hydrogel network gave the composite hydrogel the ability to self-heal and continuously release baicalin and boron ions.Importantly,baicalin and borate ions in Bai-B/BC composite hydrogel dressing played a synergistic pharmacological role in wound healing.The in vitro results showed that the Bai-B/BC hydrogel had excellent biocompatibility,antibacterial activity and antiinflammatory effects in comparison with the control group and other hydrogel groups.Further in vivo studies displayed that the Bai-B/BC hydrogel significantly accelerated the healing process of chronic wound by promoting uniform and orderly collagen deposition,granulation tissue formation and vascular regeneration.The Bai-B-based self-assembled hydrogel is set to become a star dressing in the treatment of chronic wounds.

关 键 词：BAICALIN Borate ions Composite hydrogel Antibacterial activity ANTI-INFLAMMATORY Wound healing 

分 类 号：TQ427.26[化学工程]