Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome  

作　　者：Qian Chen Haiqin Chen Jianxin Zhao Wei Chen Gang Wang 

机构地区：[1]State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China [4]Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China

出　　处：《Food Science and Human Wellness》2024年第6期3301-3310,共10页食品科学与人类健康（英文）

基　　金：funded by the National Natural Science Foundation of China(32021005);the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP51501);the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province.

摘　　要：The decline in ovarian estrogen production is known to have detrimental health consequences and negatively affect the quality of life in menopausal women.Increasing estradiol levels is key to preventing disease in menopausal women.In this study,Lactobacillus gasseri CCFM1255 isolated from healthy infants was found to have a positive effect on estradiol production in ovariectomized rats.CYP19,the key enzyme catalysing the conversion of androgens into estrogens,was upregulated in adipose tissue upon CCFM1255 treatment.Untargeted metabolome analysis and targeted metabolite detection were used to identify the key metabolites altered by CCFM1255 treatment.CCFM1255 treatment significantly improved the serum concentration of glutamine(Gln).A significantly positive correlation was observed between serum Gln and estradiol concentrations.CCFM1255 treatment reshaped the structure of the gut microbiome,which was correlated with certain changes in serum metabolite concentrations.These results indicate that the provision of CCFM1255 as a dietary supplement may be an effective strategy to alleviate menopausal symptoms by increasing circulating estradiol.

关 键 词：ESTRADIOL AROMATASE Gut microbiota Amino acids 

分 类 号：TS201.4[轻工技术与工程—食品科学]