Structural and functional evidence that GPR30 is not a direct estrogen receptor  

作　　者：Heng Liu Shimeng Guo Antao Dai Peiyu Xu Xin Li Sijie Huang Xinheng He Kai Wu Xinyue Zhang Dehua Yang Xin Xie H.Eric Xu 

机构地区：[1]The State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China [2]The State Key Laboratory of Chemical Biology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China [3]University of Chinese Academy of Sciences,Beijing,China [4]The Shanghai Advanced Electron Microscope Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China [5]School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang,China [6]Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai,Shandong,China [7]School of Life Science and Technology,ShanghaiTech University,Shanghai,China

出　　处：《Cell Research》2024年第7期530-533,共4页细胞研究（英文版）

基　　金：the National Natural Science Foundation of China(82121005 to X.X.,H.E.X.and D.Y.,32130022 to H.E.X.,82330113 to X.X.,82273985 to D.Y.,82304579 to S.G.);CAS Strategic Priority Research Program(XDB37030103 to H.E.X.);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to H.E.X.);Shanghai Municipal Science and Technology Major Project(H.E.X.);the Lingang Laboratory(LG-GG-202204-01 to H.E.X.);the National Key R&D Program of China(2022YFC2703105 to H.E.X.);Shanghai Municipality Science and Technology Development Fund(21JC1401600 to D.Y.);Program of Shanghai Academic/Technology Research Leader(23XD1400900 to D.Y.).

摘　　要：ear Editor,Estrogen is a pivotal hormone in human physiology,orchestrating a wide range of biological processes ranging from reproductive functions to cardiovascular health and bone integrity.1 The orphan receptor GPR30 has been hypothetically conceived as a G protein-coupled estrogen receptor that directly binds estrogen.

关 键 词：GPR30 ESTROGEN CARDIOVASCULAR 

分 类 号：R363[医药卫生—病理学]