CARNOSOL

作品数：5被引量：6H指数：1
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相关领域：医药卫生生物学更多>>
相关作者：王辉王保怀曾慧慧屠鹏飞卢景芬更多>>
相关机构：北京大学电子科技大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Journal of Structural Chemistry》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
相关基金：国家自然科学基金重庆市科技攻关计划更多>>
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Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第6期513-528,共16页Miao CHU Guangdong CHEN Kai CHEN Pengfei ZHU Zhen WANG Zhonglai QIAN Huaqiang TAO Yaozeng XU Dechun GENG 
supported by the National Natural Science Foundation of China(Nos.82272157,82072425,and 82072498);the Natural Science Foundation of Jiangsu Province(No.BE2021650);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,the Program of Suzhou Health Commission(Nos.GSWS2022002 and GSWS2020121);the Jiangsu Medical Research Project(No.ZD2022014);the National and Local Engineering Laboratory of New Functional Polymer Materials(No.SDGC2205);the Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou(No.LCZX202003),China.
Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the elderly.Osteoclast activation plays a crucial role in the occurrence of subchondral bone loss in early OA.However,the specific mechanism of osteoclast...
关键词：OSTEOCLAST Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) CARNOSOL 
Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival被引量：4
《Acta Pharmacologica Sinica》2011年第1期62-69,共8页Chien-chung CHEN Hui-ling CHEN Chia-wen HSIEH Yi-ling YANG Being-sun WUNG 
Aim： To explore whether glutathione （GSH） increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 ceils. Methods： Human hepatoma cell line HepG2 were exposed to rosemarry ...
关键词：CARNOSOL GLUTATHIONE Nrf2 NF-KB human hepatoma cell line HepG2 CYTOPROTECTION 
Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion被引量：1
《World Journal of Gastroenterology》2009年第26期3240-3245,共6页Ji-Hong Yao Xue-Song Zhang Shu-Sen Zheng Ying-Hua Li Li-Ming Wang Zhen-Zhen Wang Liang Chu Xiao-Wei Hu Ke-Xin Liu Xiao-Feng Tian 
Supported by The grants from the Dalian Scientific Research Foundation,No.2004 B3SF 143,No.2007 J21JH006;National Natural Science Foundation,No.30872449
AIM： To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion （I/R）. METHODS： Rats were divided randomly into three experimental groups： sham, intestin...
关键词：CARNOSOL Liver injury Ischemia reperfusion Nuclear factor κB 
Two Phenolic Diterpenes as Antioxidants
《Chinese Journal of Structural Chemistry》2005年第2期219-225,共7页曹槐  李涛洪  李聪  潘蓄林  宋仲容  谢小光  
This work was supported by the Fund of Yunnan Province-ChineseAcademy of Sciences Cooperation (2000YK-01); the Science and Technology Plant of Education Committee of Chongqing (B3-6-61)
A DFT study was carried out to investigate the structure-activity relationship of rosmanol and carnosol. The geometry, HOMO and LUMO of parent molecules, O–H bond dissociation energy (BDE), and distribution of unpa...
关键词：rosmanol CARNOSOL DFT antioxidant properties 
Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis被引量：1
《Acta Pharmacologica Sinica》2001年第12期1094-1098,共5页曾慧慧 屠鹏飞 周侃 王辉 王保怀 卢景芬 
National Research Laboratories of Natural and Biomimetic Drugs (No zds9604);National Natural Science Foundation of China (No 39600183)
AIM: To investigate the inhibition capacities of carnosol, rosmanol, and epirosmanol, which are phenolic diterpenes from Rosmarinus officinalis, to oxidized low-density lipoprotein (LDL) formation in human blood and d...
关键词：ANTIOXIDANTS LDL lipoproteins free radicals CARNOSOL 
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