Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor  

作　　者：Hideyuki Kobayashi M.Alaa Terkawi Masahiro Ota Tomoka Hasegawa Tomomaya Yamamoto Tomohiro Shimizu Dai Sato Ryo Fujita Toshifumi Murakami Norio Amizuka Norimasa Iwasaki Masahiko Takahata 

机构地区：[1]Department of Orthopaedic Surgery,Faculty of Medicine and Graduate School of Medicine,Hokkaido University,Sapporo 060-8638,Japan [2]Department of Developmental Biology of Hard Tissue,Graduate School of Dental Medicine,Hokkaido University,Sapporo,Japan [3]Department of Orthopaedic Surgery,Dokkyo Medical University,Mibu Shimotsuga 321-0293,Japan

出　　处：《Bone Research》2024年第3期571-581,共11页骨研究（英文版）

基　　金：supported by a Grant-in-Aid for Exploratory Research from the Ministry of Education,Culture,Sports,Science,and Technology of Japan 17H04309 (MT);the Mitsubishi foundation。

摘　　要：DNAX-associated protein 12 kD size(DAP12)is a dominant immunoreceptor tyrosine-based activation motif(ITAM)-signaling adaptor that activates costimulatory signals essential for osteoclastogenesis.Although several DAP12-associated receptors(DARs)have been identified in osteoclasts,including triggering receptor expressed on myeloid cells 2(TREM-2),C-type lectin member 5 A(CLEC5A),and sialic acid-binding Ig-like lectin(Siglec)-15,their precise role in the development of osteoclasts and bone remodeling remain poorly understood.In this study,mice deficient in Trem-2,Clec5a,Siglec-15 were generated.

关 键 词：REMODELING OSTEOCLAST stimulating 

分 类 号：R68[医药卫生—骨科学]