Engineered extracellular vesicles:Regulating the crosstalk between the skeleton and immune system  

作　　者：Wei-Wei Yu Qian-Qian Wan Yu Wei Yu-Tao Li Qi-Hong Li Tao Ye Ke-Hui Xu Jing-Han Song Chen Lei Mei-Chen Wan Kai Jiao Franklin R Tay Li-Na Niu 

机构地区：[1]State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology,School of Stomatology,the Fourth Military Medical University,Xi’an,Shaanxi 710032,China [2]Department of Stomatology,the Fifth Medical Centre,Chinese PLA General Hospital,Dongda Street,Beijing 100071,China [3]The Dental College of Georgia,Augusta University,Augusta,Georgia,United States

出　　处：《Engineered Regeneration》2022年第3期270-282,共13页再生工程（英文）

基　　金：supported by grant 2019KB01 from the State Key Laboratory of Military Stomatology,China,grant 81870805 from the National Nature Science Foundation of China,grant 2020TD-033 from the Shaanxi Key Scientific and Technological Innovation Team and by Innovative research team of high-level local universities in shanghai,Oral and maxillofacial regeneration and functional restoration.

摘　　要：Osteoimmunology has gained momentum in recent years,focusing on the crosstalk between the skeleton and the immune system.Extracellular vesicles(EVs)are nanoscale vesicles that are potential candidates for cell-free tissue regeneration strategies.They may be used for repairing damaged tissues and regulating the body’s immune system and bone-related metabolic activities.Because of the ability of EVs to deliver bioactive signals and mediate intercellular communication,they can decipher the complex mechanisms of interaction within the“osteoimmune system”at the molecular level.To address the lack of targeting ability caused by vesicle heterogeneity in the clinical applications of EVs,these nanoscopical entities may be modified by bioengineering techniques to optimize the interaction between bone repair and immunomodulation for improving treatment efficacy,specificity and safety.In the present review,the endogenous properties that make EVs natural delivery agents are outlined.Properties that may be improved by bioengineering are highlighted.The therapeutic applications of EVs in the rehabilitation of bone defects are discussed.The opportunities and challenges that need to be addressed for translating this field of research into clinical practice are brought into perspectives.

关 键 词：Bone defect CROSSTALK Engineered extracellular vesicles Immune regulation OSTEOIMMUNOLOGY 

分 类 号：R681[医药卫生—骨科学]