CHONDROCYTES

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AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration
《中国组织工程研究》2025年第17期3537-3547,共11页Yu Yangyi Song Zhuoyue Lian Qiang Ding Kang Li Guangheng 
国家自然科学基金面上项目(81472136),项目负责人:李广恒。
BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent years.However,given the complexity of osteoarthritis pathogenesis,single gene ma...
关键词：OSTEOARTHRITIS adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes. 
Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
《Genes & Diseases》2025年第2期383-397,共15页Changyuan Huangg Bin Zeng Bo Zhou Guanming Chen Qi Zhang Wenhong Hou Guozhi Xiao Li Duan Ni Hong Wenfei Jin 
supported by the National Key R&D Program of China (No.2021YFF1200900);National Natural Science Foundation of China (No.32170646,8197211);Guangdong Basic and Applied Basic Research Foundation (China) (No.2023A1515011908 to N.H.);Key-Area Research and Development Program of Guangdong Province,China (No.2023B1111020006);International Science and Technology CooperationnProgramnofGuangdong,China (No.2021A0505030011);Shenzhen Innovation Committee of Science and Technology (Guangdong,China) (No.JCYJ20220818100401003);Shenzhen Science and Technology Program (Guangdong,China) (No.SGDX20201103095800003,GJHZ20200731095606019,JCYJ20220818100401003);Shenzhen High-level Hospital Construction Fund (Guangdong,China) (No.1801004).
Chondrocyte is considered the only cell type in cartilage.However,the cell hetero-geneity of chondrocytes in human articular cartilage is still not well defined,which hinders our understanding of the pathogenesis of o...
关键词：Cell heterogeneity Chondrocyte apoptosis Chondrocyte differentiation Chondrocyte fibrosis OSTEOARTHRITIS Single-cell RNA-seq 
Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes
《Genes & Diseases》2025年第2期425-437,共13页Pan Li Chao Zheng Jingyan Hu Weiguang Lu Dong Wang Xue Hao Chengxiang Zhao Liu Yang Zhuojing Luo Qiang Jie 
supported by the National Natural Science Foundation of China (No.82272442,82372361);the Key Industrial Chain Program of Shaanxi,China (No.2022ZDLSF02-12).
Although the pathogenesis and mechanism of congenital skeletal dysplasia are bet-ter understood,progress in drug development and intervention research remains limited.Here we report that melatonin treatment elicits a ...
关键词：Ca^(2+)overload CHONDRODYSPLASIA Endoplasmic reticulum stress MELATONIN SLC26A2 
Nanoengineered cargo with targeted in vivo Foxo3 gene editing modulated mitophagy of chondrocytes to alleviate osteoarthritis
《Acta Pharmaceutica Sinica B》2025年第1期571-591,共21页Manyu Chen Yuan Liu Quanying Liu Siyan Deng Yuhan Liu Jiehao Chen Yaojia Zhou Xiaolin Cui Jie Liang Xingdong Zhang Yujiang Fan Qiguang Wang Bin Shen 
supported by the National Key Research and Development Project of China(2023YFB4605800);the Natural Science Foundation of China(32071353 and 82272561);the Natural Science Foundation of Sichuan Province(2024NSFSC0671,China);the 111 Project of China(B16033).
Mitochondrial dysfunction in chondrocytes is a key pathogenic factor in osteoarthritis(OA),but directly modulating mitochondria in vivo remains a significant challenge.This study is the first to verify a correlation b...
关键词：OSTEOARTHRITIS MITOPHAGY Nanoengineered cargo 
Chondrogenic commitment of human umbilical cord blood and umbilical cord-derived mesenchymal stem cells induced by the supernatant of chondrocytes:A comparison study
《Animal Models and Experimental Medicine》2024年第6期793-801,共9页Xingfu Li Zhenhan Deng Wei Lu 
National Natural Science Foundation of China,Grant/Award Number:82072515;Basic Public Welfare Research projects of Wenzhou Science and Technology Bureau,Grant/Award Number:Y20240087;Start-up Funding for Talented Scientific Research of the First Affiliated Hospital of Wenzhou Medical University,Grant/Award Number:2023QD026;Shenzhen Science and Technology Projects,Grant/Award Number:JCYJ20220530150615035。
Background:Native cartilage has low capacity for regeneration because it has very few progenitor cells.Human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs)and human umbilical cord-derived MSCs(hUC-MSCs...
关键词：cartilage diseases chondrogenic differentiation mesenchymal stem cells 
Preliminary Study on the Differentiation of Bone Marrow Mesenchymal Stem Cells into Chondrocytes Induced by TGF-β1, Yougui Yin Drug-Containing Serum and Mechanical Stimulation
《Journal of Biosciences and Medicines》2024年第12期219-228,共10页Zengping Lin Kanghua Zheng Darong Nie Huoquan Ye Hongjie Zhang Linfeng Tang Zhong Dong 
Objective: Bone marrow mesenchymal stem cells (BMSCs) have the potential to differentiate into chondrocytes, it is the ideal seed cells for treating cartilage injury. The purpose of this study was to investigate the i...
关键词：BMSCs Yougui Yin Drug-Containing Serum TGF-Β1 Mechanical Stimulation PLGA Chondrocyt 
Arctiin Protects Chondrocytes from Interleukin-1β-Induced Inflammation and Apoptosis by RNA Sequence In vivo and In vitro
《World Journal of Traditional Chinese Medicine》2024年第4期495-511,共17页Yong-Jia Song Jia-Min Bao Zeng-Qiao Zhang Yun-Xiang Hai Hao-Nan Wen Tian-Jun Zhai Wei Feng Min Song 
supported by the National Natural Science Foundation of China (81873328)
Objective:Osteoarthritis(OA) is a progressive joint disease characterized by degeneration and de struction of articular cartilage.Arctiin(ARC) has been shown in many studies to have potential anti-inflammatory,anti-ap...
关键词：APOPTOSIS ARCTIIN CHONDROCYTES INFLAMMATION OSTEOARTHRITIS RNA‑sequencing 
Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling被引量：1
《Genes & Diseases》2024年第2期964-977,共14页Chengzhi Wu Hengyu Liu Dongmei Zhong Xiaoming Yang Zhiheng Liao Yuyu Chen Shun Zhang Deying Su Baolin Zhang Chuan Li Liru Tian Caixia Xu Peiqiang Su 
supported by the National Natural Science Foundation of China(No.92068105,82172376,82072385).
Mutation of the MAPK7 gene was related to human scoliosis.Mapk7 regulated the development of limb bones and skulls in mice.However,the role of MAPK7 in vertebral development is still unclear.In this study,we construct...
关键词：Chondrocyte hypertrophy Growth plate KYPHOSIS MAPK7 MEF2C OSTEOPENIA PI3K/AKT PTEN 
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development被引量：1
《Bone Research》2024年第1期199-214,共16页Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke 
supported by the German Research Foundation(SCHI 504/19-1(to TS)and IG 18/22-1(to AI));the Else Kröner-Fresenius foundation under grant no.2021_EKEA.23(to TR);financial support from the Open Access Publication Fund of UKE–Universitatsklinikum Hamburg-Eppendorf and DFG–German Research Foundation.
Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell types.While we and others have previously demonstrated that the expression of Piezo1 in osteo...
关键词：Piezo1 markedly OSSIFICATION 
Exploring the effect of Bushen Bitong recipe-containing serum on IL-1β-induced chondrocyte apoptosis based on SOX9/NF-κB/MMP-13 signaling pathway
《Journal of Hainan Medical University》2024年第4期1-7,共7页YI Lin ZHANG Wen-hao XIANG Wen-yuan SHI Zheng-yu REMILA Aimai-ti DENG Ying-jie FANG Rui 
National Natural Science Foundation of China(No.82360934);Science and Technology Innovation Leading Talents Project of Xinjiang Uygur Autonomous Region(No.2022TSYCLJ0007);Xinjiang Uygur Autonomous Region Key Research and Development Task Special Project(No.2021B03006);Natural Science Foundat ion of Xinj iang Uygur Autonomous Region(No.2022D01C170,2022D01C171)。
Objective:To observe the effect and possible mechanism of action of Bushen Bitong recipe(BSBT)containing serum on IL-1β-induced chondrocyte apoptosis.Methods:Generation 3 rat chondrocytes were randomized into Control...
关键词：Bushen Bitong recipe Osteoarthritis CHONDROCYTES Signaling pathway IL-1Β 
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