Degradation particles derived from high-purity magnesium inhibit osteogenic differentiation through regulation of macrophage polarization  

作　　者：Yu Sun Han Yu Hongzhou Peng Xinbao Kang Zhaoxiang Peng Xieping Dong Wenhui Wang Yang Song Xiaonong Zhang 

机构地区：[1]State Key Laboratory of Metal Matrix Composites,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [2]Department of Orthopaedic Surgery,Ningbo Medical Treatment Center Lihuili Hospital,Ningbo 315040,China [3]Department of Orthopaedic Surgery,Jiangxi People’s Hospital,Nanchang 330006,China [4]Suzhou Origin Medical Technology Co.Ltd.,Jiangsu 215513,China

出　　处：《Journal of Materials Science & Technology》2023年第8期113-119,共7页材料科学技术（英文版）

基　　金：This work was financially supported by the Natural Science Foundation of China(No.82160436);the Science and Technol-ogy Commission of Shanghai Municipality(No.19441905600);the“Science and Technology Innovation 2025Major Special Project of Ningbo(No.2019B10064);the Shanghai Jiao Tong Univer-sity Interdisciplinary(Biomedical Engineering)Research Fund(No.ZH2018ZDA09);China Postdoctoral Science Foundation(No.2021M702090).

摘　　要：Magnesium(Mg)and its alloys have great potential as orthopedic implant candidates,which could release various bioactive substances during degradation.Degradation particles(DPs)are one of the degradation products,but the osteoimmunology effects are still unclear.In this study,the effect of DPs on the polar-ization of macrophages and their release of cytokines was investigated.The results verify that excessive generation of DPs from biodegradable Mg can induce macrophages to realize polarization of proinflamma-tory M1 phenotype.Moreover,macrophages secrete proinflammatory cytokines to inhibit the osteogenic differentiation of rat bone marrow stem cells(rBMSCs).This suggests that the effects of DPs should be considered when evaluating Mg-based implants.DPs continuously produced with the degradation of Mg-based implants may influence osseointegration.

关 键 词：MAGNESIUM Degradation particles Macrophage PHAGOCYTOSIS OSTEOIMMUNOLOGY 

分 类 号：R318[医药卫生—生物医学工程]