SIK2 promotes malignant features of human osteosarcoma via up-regulating MMP2 andβ-catenin expression  

作　　者：Yutong Wang Yulan Yao Sen Kou Shanshan Wang Juntao Song Siqi Yang Hongwei Wang Yunliang Wang 

机构地区：[1]School of Public Health and Laboratory of Qilu Medical University,Zibo,Shandong 255300,China [2]Department of Neurology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450014,China [3]Department of Neurology,Zibo 148 Hospital,Zibo,Shandong 255300,China [4]Department of Oncology and Hematology,Zibo.148 Hospital,Zibo,Shandong 255300,China [5]School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China

出　　处：《Genes & Diseases》2025年第2期83-85,共3页基因与疾病(英文)

摘　　要：Osteosarcoma is a primary malignant bone tumor that commonly occurs in children and adolescents.It is highly malignant and prone to metastasis,with a very poor prognosis.There is currently no effective treatment for this disease.1 SIK2(salt-inducible kinase 2),which is located on human chromosome 11,belongs to the AMPK(AMP-activated protein kinase)family that regulates energy metabolism.

关 键 词：MALIGNANT OSTEOSARCOMA METASTASIS 

分 类 号：R73[医药卫生—肿瘤]