supported by grants from the National Natural Science Foundation of China(Nos.82374489,U20A20259 and 22201299);the Scientific Research Program of the Tianjin Municipal Education Commission(No.2021ZD013)。
Osteoarthritis(OA)is the most prevalent joint disease and icariin is a promising drug for its treatment.However,the clinical use of icariin is hindered by poor water solubility,low bioavailability,and nonspecific rele...
supported by the National Natural Science Foundation of China (U20A20259, 22201141);the Fundamental Research Funds for the Central Universities;the NCC Fund(NCC2020FH04);the China Postdoctoral Science Foundation(2022M711697)。
Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, including mo...
Currently a technique widely used for gold extraction is mercury by amalgamation technique, the tailing produced pollutes water of all kinds, so it is necessary to develop a form of selective mitigation, for which it ...
the CSIR and DBT for supporting this study;Mizoram University,Aizawl,Mizoram,India,for the MZU-UGC fellowship。
Macrocyclic supramolecular complexes demonstrate the dynamic potential to solve global biomedical challenges,a promising cancer treatment modality.The macrocyclic system is an important heterocyclic system widely pres...
supported by the National Key R&D Program of China(nos.2019YFA0904200 and 2018YFA0507600);the Tsinghua University Spring Breeze Fund(no.2020Z99CFY042);the National Natural Science Foundation of China(nos.92053108 and 31961143004);NCC Fund(no.NCC2020FH04).
Stimulator of interferon genes,namely STING,an adaptor protein located in the endoplasmic reticulum,has been recognized as a shining target for cancer and infection research.However,STING agonists cyclic dinucleotides...
supported by the National Natural Science Foundation of China (Nos.U20A20259,31961143004);the Nankai University&Cangzhou Bohai New Area Institute of Green Chemical Engineering Fund,China (No.NCC2020FH04).
Nucleotides participate in various physiological processes through their supramolecular interactions with biomolecules.Therefore,the molecular recognition of nucleotides became an important topic in supramolecular che...
the financial support from the National Natural Science Foundation of China (Nos. 21572026, 21702019);Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX20_2525);Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University;the analytical testing support from Analysis and Testing Center, NERC Biomass of Changzhou University
A calix[4]arene ligand assisted directβ-C-H arylation of tertiary aliphatic aldehydes has been developed via a Pd-catalyzed C(sp3)-H functionalization process.This strategy exhibited good functional group compatibili...
National Key Research and Development Programs of China(No.2018YFA0209700);National Natural Science Foundation of China(NSFC,No.22077073);Frontiers Science Center for New Organic Matter(No.63181206);Fundamental Research Funds for the Central Universities(Nankai University,No.63206015).
Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer drugs.However,the complicated synthesis during the preparation as well as the potential ...
National Natural Science Foundation of China,Grant/Award Numbers:22007044,92053108;National Key Research and Development Program of China,Grant/Award Numbers:2018YFA0507600,2019YFA0904200;Natural Science Foundation of Fujian Province,Grant/Award Number:2020J01864;Talent Introduction Fund of Minjiang University,Grant/Award Number:MJY19025。
The aggregation of amyloid proteins has been suggested to be the main cause of multiple human disorders;for example,amyloidβaggregates in Alzheimer’s disease andα-synuclein aggregates in Parkinson’s disease.In the...
sponsored by the National Natural Science Foundation of China(Nos.22071104,21871136).
The mixture of p-(methoxy)calix[n]arenes(n=6,7 or 8)was prepared in one step from p-methoxyphenol under basic conditions,and their fully methylated derivatives p-(dimethyloxy)calix[n]arenes(n=6,7 or 8)were also prepar...