Macrocyclic supramolecular biomaterials in anti-cancer therapeutics  

作　　者：Biki Hazarika Ved Prakash Singh 

机构地区：[1]Department of Chemistry,School of Physical Sciences,Mizoram University,Aizawl,Mizoram 796004,India [2]Department of Industrial Chemistry,School of Physical Sciences,Mizoram University,Aizawl,Mizoram 796004,India

出　　处：《Chinese Chemical Letters》2023年第11期98-115,共18页中国化学快报（英文版）

基　　金：the CSIR and DBT for supporting this study;Mizoram University,Aizawl,Mizoram,India,for the MZU-UGC fellowship。

摘　　要：Macrocyclic supramolecular complexes demonstrate the dynamic potential to solve global biomedical challenges,a promising cancer treatment modality.The macrocyclic system is an important heterocyclic system widely present in natural products and synthetic molecules.The unique structural feature of macrocyclic supramolecular complexes with desirable donor&acceptor characteristics is beneficial for readily binding with various enzymes and receptors in biological systems through diverse weak interactions,thereby exhibiting broad bioactivities.Macrocyclic-related research and macrocyclic moleculesbased medicinal chemistry developments have become rapidly developing areas of study.Numerous macrocyclic-based molecules as clinical drugs have been extensively used in the clinic to treat various diseases with high therapeutic potency.This critically analyzed work systematically reviews current developments of macrocyclic supramolecular complexes-based compounds in the range of medicinal chemistry as anticancer,anti-inflammatory,and other therapeutic agents,together with their potential applications in diagnostics and pathology.This review will be helpful for medicinal chemistry researchers to develop new thoughts in the quest for rational designs of more active and less toxic macrocyclic supramolecular complexes-based medicinal drugs,as well as more effective diagnostic agents and pathologic probes.

关 键 词：SUPRAMOLECULAR Weak interactions Self-assembly DRUG-DELIVERY Cancer Nano Tumor targeted CALIXARENE CUCURBITURIL In vivo bioimaging 

分 类 号：O62[理学—有机化学]