supported by the China Postdoctoral Science Foundation(No.2022M712252);the Natural Science Foundation of Sichuan Province,China(No.2023NSFSC1634).
Viral myocarditis(VMC)is one of the most common acquired heart diseases in children and teenagers.However,its pathogenesis is still unclear,and effective treatments are lacking.This study aimed to investigate the regu...
supported by several key projects,the Medical and Health Science and Technology Innovation Project of the Chinese Academy of Medical Sciences(CIFMS,2016-I2M-2-001);the National Resource Center for Non-Human Primates,Major Science and Technology Special Projects in Yunnan Province,Kunming Science and Technology Innovation and Service Capacity Enhancement Program Key Projects(2016-2-R-07674);the CAMS Innovation Fund for Medical Sciences(CIFMS,2018-I2M-3-002 and 2021-I2M-1-024);the National Key R&D Project of China(2021YFF0702804);Peking Union Medical College-Central University Basic Scientific Research Business Fee(Project number.:3332023079);Yunnan Province Applied Basic Research Special Project-General Project(project number:202401CF070048,202301AT070367).
Coxsackievirus B3(CVB3)is the pathogen causing hand,foot and mouth disease(HFMD),which manifests across a spectrum of clinical severity from mild to severe.However,CVB3-infected mouse models mainly demonstrate viral m...
supported by Affiliated Hospital of Youjiang Medical University for Nationalities(No.Y20212615).
Objective:To explore the mechanism by which icariin alleviates viral myocarditis.Methods:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on ce...