Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system:current status and future perspective  

作　　者：Song-Po Liu Yun-Fei Li Dan Zhang Chun-Yang Li Xiao-Fang Dai Dong-Feng Lan Ji Cai He Zhou Tao Song Yan-Yu Zhao Zhi-Xu He Jun Tan Ji-Dong Zhang 

机构地区：[1]Department of Immunology,Zunyi Medical University,Zunyi 563000,China [2]Special Key Laboratory of Gene Detection and Therapy of Guizhou Province,Zunyi Medical University,Zunyi 563000,China [3]Department of Medical Genetics,Zunyi Medical University,Zunyi 563000,China [4]Department of Respiratory Medicine,The Third Affiliated Hospital of Zunyi Medical University(The First People’s Hospital of Zunyi),Zunyi 563000,China [5]Zunyi Medical University Library,Zunyi 563000,China [6]Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine,Zunyi Medical University,Zunyi 563000,China [7]Department of Histology and Embryology,Zunyi Medical University,Zunyi 563000,China

出　　处：《Asian Journal of Andrology》2025年第1期20-29,共10页亚洲男性学杂志(英文版)

基　　金：supported by the National Nature Science Foundation of China(NSFC,No.31960156,No.31660338,No.31760627,and No.32270848);Collaborative Innovation Center of Chinese Ministry of Education(2020-39),Science and Technology Support Program of Guizhou Province(QKH[2021]111,QKH[2020]4Y192,QKH[2018]5772-006,and QKH[2019]5406);Science and Technology Fund of Guizhou Provincial Health Commission(gzwkj2022-019).

摘　　要：Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects,especially in improving sexual function,hormone regulation,anti-osteoporosis,immune function regulation,anti-oxidation,and anti-tumor activity.To date,we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system.However,their actions in other tissues have been reviewed in recent years.This review critically focuses on the Epimedium,its bioactive compounds,and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system.Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders.

关 键 词：EPIMEDIUM ICARIIN INFERTILITY male reproductive system TUMOR 

分 类 号：R285[医药卫生—中药学]