Gut microbiota plays a key role in the development of colorectal cancer  

作　　者：Ying-Ling Liu Jie Liu 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of University of Science and Technology of China(USTC),Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,Anhui Province,China

出　　处：《World Journal of Gastroenterology》2025年第14期168-171,共4页世界胃肠病学杂志(英文)

基　　金：Supported by Research Project of the Chinese Digestive Early Cancer Physicians'Joint Growth Program,No.GTCZ-2021-AH-34-0012.

摘　　要：This letter addresses the recently published manuscript by Darnindro et al,which investigates the diversity and composition of colonic mucosal microbiota in Indonesian patients with and without colorectal cancer(CRC).Although the analysis revealed no statistically significant differences in alpha diversity between the CRC and non-CRC groups,the authors identified notable distinctions in the composition and diversity of colonic mucosal microbiota among patients with CRC compared to those without.At the genus level,a statistically significant difference in microbiota composition was documented between the two cohorts.Specifically,the genera Bacteroides,Campylobacter,Peptostreptococcus,and Parvimonas were found to be elevated in individuals with CRC,while Faecalibacterium,Haemophilus,and Phocaeicola were more prevalent in the non-CRC group.

关 键 词：Colorectal cancer Gut microbiota Microbial dysbiosis Intratumoral microbiota Gut metabolites 

分 类 号：R73[医药卫生—肿瘤]