Amyloid-βis NOT only the most promising target for Alzheimer’s disease  

作　　者：Beka Solomon Milana Voronov-Goldman 

机构地区：[1]Department of Molecular Microbiology and Biotechnology,The Shmunis School of Biomedicine and Cancer Research,the George S.Wise Faculty of Life Sciences Tel-Aviv University,Ramat Aviv,Israel

出　　处：《Neural Regeneration Research》2026年第2期681-682,共2页中国神经再生研究(英文版)

摘　　要：Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD pathology-the amyloid cascade hypothesis-highlights the pivotal role of increased processing of the amyloid precursor protein(APP).Initially cleaved by the majorβ-secretase(β-amyloid cleaving enzyme-1,BACE1)in the brain,then undergoes further cleavage by theγ-secretase complex,resulting in the production of Aβ_(40-42)and a set of intracellular C-terminal peptides known as Aβand APP intracellular domain(β-AICDs)and soluble amyloid precursor proteinβ(sAPPβ)(Orobets and Karamyshev,2023).

关 键 词：amyloid precursor protein app initially intracellular peptides amyloid cascade hypothesis amyloid cascade hypothesis highlights AMYLOID tau Alzheimers disease SECRETASE 

分 类 号：R749.1[医药卫生—神经病学与精神病学]