p21 as an essential regulator of neurogenic homeostasis in neuropathological conditions  

作　　者：Valentina Mastrorilli Stefano Farioli-Vecchioli 

机构地区：[1]Institute of Biochemistry and Cell Biology,IBBC,CNR,Monterotondo,Rome,Italy

出　　处：《Neural Regeneration Research》2026年第2期675-676,共2页中国神经再生研究(英文版)

基　　金：supported by PRIN/MUR funding(to VM).

摘　　要：Adult neurogenesis is a highly dynamic process that leads to the production of new neurons from a population of quiescent neural stem cells(NSCs).In response to specific endogenous and/or external stimuli,NSCs enter a state of mitotic activation,initiating proliferation and differentiation pathways.Throughout this process,NSCs give rise to neural progenitors,which undergo multiple replicative and differentiative steps,each governed by precise molecular pathways that coordinate cellular changes and signals from the surrounding neurogenic niche.

关 键 词：adult neurogenesis quiescent neural stem cells nscs precise molecular pathways mitotic activationinitiating cellular changes neurogenic homeostasis neural progenitorswhich production new neurons 

分 类 号：R741[医药卫生—神经病学与精神病学]