The gut microbiome:implications for neurogenesis and neurological diseases  

作　　者：Cheng Liu Shang-Yu Yang Long Wang Fang Zhou 

机构地区：[1]Department of Healthcare Administration,College of Medical and Health Science,Asia University,Taichung,Taiwan,China [2]Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China

出　　处：《Neural Regeneration Research》2022年第1期53-58,共6页中国神经再生研究（英文版）

摘　　要：There is an increasing recognition of the strong links between the gut microbiome and the brain,and there is persuasive evidence that the gut microbiome plays a role in a variety of physiological processes in the central nervous system.This review summarizes findings that gut microbial composition alterations are linked to hippocampal neurogenesis,as well as the possible mechanisms of action;the existing literature suggests that microbiota influence neurogenic processes,which can result in neurological disorders.We consider this evidence from the perspectives of neuroinflammation,microbial-derived metabolites,neurotrophins,and neurotransmitters.Based on the existing research,we propose that the administration of probiotics can normalize the gut microbiome.This could therefore also represent a promising treatment strategy to counteract neurological impairment.

关 键 词：gut microbiota microbial-derived metabolites microbiota-gut-brain axis NEUROGENESIS NEUROINFLAMMATION neurological diseases NEUROTROPHINS PROBIOTICS 

分 类 号：R741.02[医药卫生—神经病学与精神病学]