Association of neonatal blood levels of brain-derived neurotrophic factor with development of autism spectrum disorder:a systematic review and meta-analysis  

作　　者：Ya-Kun Liu Hua Gao Shao-Bin Jin Wen-Jun Tu Ya-Jun Chen 

机构地区：[1]Department of General Surgery,Beijing Children’s Hospital,Capital Medical University,No.56 Nanlishi St.Beijing 100045,China [2]Department of Pediatric Surgery,Qilu Hospital of Shandong University,No.107 West Wenhua St,Jinan 250000,China [3]Institute of Radiation Medicine,Chinese Academy of Medical Science,Peking Union Medical College,No.238 Baidi St,Tianjin 300192,China [4]Key Lab of Cerebral Microcirculation in Universities of Shandong,Shandong First Medical University,Shandong Academy of Medical Sciences,No.619 Changcheng St.Taian 271000,China

出　　处：《World Journal of Pediatrics》2021年第2期164-170,共7页世界儿科杂志（英文版）

基　　金：This study was supported by grants from CAMS Innovation Fund for Medical Science(Nos.2017-I2M-1-016 and 2019-I2M-2-006);Natural Science Foundation of Tianjin(No.19JCYBJC26600);China Postdoctoral Science Foundation(Nos.2019M660921 and 2020T130436);Science Foundation for Post Doctorate Research of the Beijing(Nos.2017-ZZ-123 and 2020-ZZ-005);Youth Backbone Project from Chinese Academy of Medical Science Institute of Radiation Medicine(No.2019043).

摘　　要：Background Our goal was to evaluate the association between neonatal blood brain-derived neurotrophic factor(BDNF)level and autism spectrum disorder(ASD)diagnosis later in life.Methods MEDLINE and Web of Science databases were searched from inception until September 16,2020.Reference lists of all relevant articles also were reviewed.Mean blood BDNF concentrations,standard deviations,sample sizes,and other data needed for calculation of effect sizes were extracted by two independent investigators.The quality of the included studies was appraised using the Newcastle-Ottawa Scale for case-control studies.Data were pooled using the random-effects model.Results Five case-control studies involving 1341 cases and 3395 controls were included in the meta-analysis.The meta-analysis of all included studies showed no significant difference in blood BDNF levels between neonates diagnosed with ASD later in life and healthy controls[standardized mean difference(SMD)=0.261;95%confidence interval(CI)-0.052 to 0.573;P=0.102],with high level of heterogeneity(Q=64.346;I2=93.784;P<0.001).A subgroup analysis by assay type showed decreased blood BDNF levels in ASDs compared to controls(SMD=—0.070;95%CI-0.114 to-0.026;P=0.002),with high level of homogeneity(Q=0.894;I2=0.000;P=0.827).No evidence of publication bias was observed.Conclusions Neonates diagnosed with ASD later in life have decreased blood levels of BDNF measured by double-antibody immunoassay.More studies are warranted to facilitate a more robust conclusion.

关 键 词：Autism spectrum disorder Autistic disorder Brain-derived neurotrophic factor NEONATES NEUROTROPHINS 

分 类 号：R749.94[医药卫生—神经病学与精神病学]