Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain  

作　　者：Joel F.Ritala Seán BLyne Antti Sajanti Romuald Girard Janne Koskimäki 

机构地区：[1]Division of Clinical Neurosciences,Department of Neurosurgery,Turku University Hospital and University of Turku,Turku,Finland [2]Neurovascular Surgery Program,Section of Neurosurgery,The University of Chicago Medicine and Biological Sciences,Chicago,IL,USA [3]Department of Psychiatry,Central Hospital of Southern Ostrobothnia,Seinäjoki,Finland [4]Neuroscience Center,HiLIFE,University of Helsinki,Helsinki,Finland

出　　处：《Neural Regeneration Research》2022年第4期701-704,共4页中国神经再生研究（英文版）

摘　　要：The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses,modify the response to injury,and alter the adaptation response.Intriguingly,the prior studies highlight the role of p75 neurotrophin receptor(p75^(NTR))in various injuries and diseases such as central nervous system injuries,Alzheimer's disease and amyotrophic lateral sclerosis.More comprehensive elucidation of the mechanisms,and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury.Due to a diverse role of the p75^(NTR)in biology,the body of evidence comprising its biological role is diffusely spread out over numerous fields.This review condenses the main evidence of p75^(NTR)for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level.

关 键 词：BIOINFORMATICS brain injury data mining NEURON NEUROTROPHINS p75^(NTR) PLASTICITY REGENERATION 

分 类 号：R741[医药卫生—神经病学与精神病学]