Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma  

作　　者：Jingbo Li Rui Kang Daolin Tang 

机构地区：[1]Department of Surgery,UT Southwestern Medical Center,Dallas,Texas 75390,USA

出　　处：《Cancer Communications》2021年第8期642-660,共19页癌症通讯（英文）

摘　　要：Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignant disease with a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous cells.Recent works have revealed that the dynamic interaction between cancer cells and neuronal cells leads to perineural invasion(PNI),a clinical pathological feature of PDAC.The formation and function of PNI are dually regulated by molecular(e.g.,involving neurotrophins,cytokines,chemokines,and neurotransmitters),metabolic(e.g.,serine metabolism),and cellular mechanisms(e.g.,involving Schwann cells,stromal cells,T cells,and macrophages).Such integrated mechanisms of PNI not only support tumor development,growth,invasion,and metastasis but also mediate the formation of pain,all of which are closely related to poor disease prognosis in PDAC.This review details the modulation,signaling pathways,detection,and clinical relevance of PNI and highlights the opportunities for further exploration that may benefit PDAC patients.

关 键 词：NEUROTROPHINS pancreatic ductal adenocarcinoma perineural invasion schwann cells tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]