Molecular mechanisms of neurite regeneration and repair:insights from C.elegans and Drosophila  

作　　者：Xiaofan Liu Yuqing Zhao Wei Zou 

机构地区：[1]The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu,China [2]Institute of Translational Medicine,Zhejiang University,Hangzhou,China [3]Institute of Zhejiang University and University of Edinburgh,Jiaxing,China

出　　处：《Cell Regeneration》2023年第1期284-294,共11页细胞再生（英文）

基　　金：supported by grants from the National Science Foundation of China(31970919)to W.Z.

摘　　要：The difficulties of injured and degenerated neurons to regenerate neurites and regain functions are more significant than in other body tissues,making neurodegenerative and related diseases hard to cure.Uncovering the secrets of neural regeneration and how this process may be inhibited after injury will provide insights into novel management and potential treatments for these diseases.Caenorhabditis elegans and Drosophila melanogaster are two of the most widely used and well-established model organisms endowed with advantages in genetic manipulation and live imaging to explore this fundamental question about neural regeneration.Here,we review the classical models and techniques,and the involvement and cooperation of subcellular structures during neurite regeneration using these two organisms.Finally,we list several important open questions that we look forward to inspiring future research.

关 键 词：Neurite regeneration Neurite repair Caenorhabditis elegans Drosophila melanogaster Genetic manipulation Live imaging Subcellular structures AXOTOMY Dendrotomy DLK-1 

分 类 号：Q96[生物学—昆虫学]