supported by grants from the Lone Star Paralysis Foundation,NIH R01NS081063;Department of Defense award W81XWH-19-2-0054 to GDB;supported by University of Wyoming Startup funds,Department of Defense grant W81XWH-17-1-0402;the University of Wyoming Sensory Biology COBRE under National Institutes of Health(NIH)award number 5P20GM121310-02;the National Institute of General Medical Sciences of the NIH under award number P20GM103432 to JSB。
Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal regeneration.Furthermore,such peripher...
Background:Traumatic facial nerve injury is the second leading cause of facial paralysis,presenting significant challenges such as difficulties with eating,speaking,impaired vision,and loss of facial expression.Unders...
This work was supported by a grant from Department of Defense Peer Reviewed Orthopaedic Research Program award(grant No.OR180077 W81XWH-19-2-0054;to GDB)。
Complete transection of peripheral mixed nerves immediately produces loss of sensory perception,muscle contractions and voluntary behavior mediated by the severed distal axons.In contrast to natural regeneration(~1 mm...
supported by the Wu Jieping Medical Foundation of China,No. 320.6750.17273 (to YBG)。
A new nerve matrix membrane derived from decellularized porcine nerves has been shown to retain the major extracellular matrix components, and to be effective in preventing adhesion between the nerve anastomosis sites...
supported by the Key Laboratory of Trauma and Neural Regeneration (Peking University),Ministry of Education of China,No. BMU2020XY005-03;National Natural Science Foundation of China,No. 31771322;Beijing Science&Technology New Star Cross Project of China,No. 201819;Major R&D Program of National Ministry of Science and Technology of China,No. 2018YFB1105504;a grant from National Center for Trauma Medicine,Beijing,China,No. BMU2020XY005-01 (all to PXZ)。
With the development of neuroscience, substantial advances have been achieved in peripheral nerve regeneration over the past decades. However, peripheral nerve injury remains a critical public health problem because o...
supported by the National Natural Science Foundation of China(General Program),No.316781246(to DYZ);the Science and Technology Fund of Health Planning Commission of Binhai New Area of Tianjin of China,No.2011BHKY008,2012BWKZ002(to KY);the National Key Research and Development Program of China,No.2016YFC1101600(to DYZ)
Small ubiquitin-like modifiers (SUMOs) have been shown to regulate axonal regeneration, signal transduction, neuronal migration, and myelination, by covalently and reversibly attaching to the protein substrates during...
In modern neuroscience,the most relevant is the study of the problem of reinnervation of tissues after severe injuries.Complete restoration of lost physiological functions is still impossible with lesions of periphera...
supported by the Basic-Clinical scientific research cooperation fund of Capital Medical University[Grant No.14JL49];;the National Natural Science Foundation of China[Grant No.31440051];Special fund for scientific research on health development in the capital[Grant No.2014-2-1073]
Objective To investigate the optimal timing for the repair of persistent incomplete facial paralysis by hypoglossal-facial ‘side'-to-side neurorrhaphy in rats. Methods A total of 30 adult rats with crushed and bulld...
Aim:The aim of the study was to provide early muscular reinnervation to avoid muscle atrophy and functional loss in an experimental model.Methods:Fifty rats were divided into five groups.In group 0(control group)only ...
Digital nerve injuries are the mostly detected nerve injury in the upper extremity. However, since the clinical phenomenon of crossover innervation at some degree from uninjured digital nerve to the in- jured side occ...